2. Gene
  3. SLC35B1 - solute carrier family 35 member B1 Gene

SLC35B1 - solute carrier family 35 member B1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 35 成员 B1

种属: Homo sapiens

同用名: AXER; UGTREL1

基因 ID: 10237 | 基因类型: protein coding

关于 SLC35B1

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,700,943-49,708,197 (from NCBI)

This gene has 20 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.3), duodenum (RPKM 18.7) and 25 other tissues.

功能概要

该基因编码的核苷酸糖转运蛋白是溶质载体家族 35 的成员。该家族中的转运蛋白是高度保守的疏水蛋白，具有多个跨膜结构域。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2013 年 7 月]

This gene encodes a nucleotide sugar transporter which is a member of solute carrier family 35. The transporters in this family are highly conserved hydrophobic proteins with multiple transmembrane domains. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

SLC35B1 基因产物(2)

mRNA Protein Name
NM_001278784.2 NP_001265713.1 solute carrier family 35 member B1 isoform 2
NM_005827.4 NP_005818.3 solute carrier family 35 member B1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP:ADP antiporter activity IDA
IDA: 通过直接分析推断
30154480 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
30154480 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC35B1 蛋白结构

UAA

UAA: UAA transporter family (16 - 315)

  • 0
  • 100
  • 200
  • 300
  • 322 a.a.
蛋白主名 其他名称

solute carrier family 35 member B1

ATP/ADP exchanger ER

SLC35B1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC35B1 P78383 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra SLC35B1 P78383 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra SLC35B1 P78383 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra SLC35B1 P78383 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra SLC35B1 P78383 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra SLC35B1 P78383 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra SLC35B1 P78383 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra SLC35B1 P78383 PTPN5 Homo sapiens P54829
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 PTPN5 Homo sapiens P54829
Y2H Array
32296183
Intra SLC35B1 P78383 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra SLC35B1 P78383 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra SLC35B1 P78383 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra SLC35B1 P78383 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra SLC35B1 P78383 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra SLC35B1 P78383 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 FZD5 Homo sapiens Q13467
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 FZD5 Homo sapiens Q13467
Validated Y2H
32296183
Intra SLC35B1 P78383 FZD5 Homo sapiens Q13467
Y2H Array
32296183
Intra SLC35B1 P78383 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra SLC35B1 P78383 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra SLC35B1 P78383 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra SLC35B1 P78383 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra SLC35B1 P78383 FKBP8 Homo sapiens Q14318
Validated Y2H
32296183
Intra SLC35B1 P78383 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra SLC35B1 P78383 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra SLC35B1 P78383 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra SLC35B1 P78383 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra SLC35B1 P78383 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 CCDC107 Homo sapiens Q8WV48
Y2H Prey Pooling
32296183
Intra SLC35B1 P78383 CCDC107 Homo sapiens Q8WV48
Validated Y2H
32296183
Intra SLC35B1 P78383 CCDC107 Homo sapiens Q8WV48
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Barre-Lieou Syndrome

Cervicocranial Syndrome

Posterior Cervical Sympathetic Syndrome
Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect

Dicarboxylicaminoaciduria

DCBXA

Renal Aminoacidurias
Bardet-Biedl Syndrome 10

BBS10

Bardet-Biedl Syndrome

Bbs

Bardet-Biedl Syndrome, Type 10
Hydranencephaly

Hydroanencephaly
Chromosome 1q21.1 Deletion Syndrome, 1.35-Mb

Chromosome 1q21.1 Deletion Syndrome

1q21.1 Microdeletion Syndrome

Monosomy 1q21.1

1q21.1 Microdeletion

Chromosome 1q21.1 Microdeletion Syndrome

1q21.1 Contiguous Gene Deletion

1q21.1 Deletion

Del(1)(Q21)

1q21.1 Deletion Syndrome
Retinitis Pigmentosa 12

RP12

Retinitis Pigmentosa With Or Without Paraarteriolar Preservation Of Retinal Pigment Epithelium

Rp With Or Without Preserved Paraarteriole Retinal Pigment Epithelium

Rp With Or Without Pprpe

Retinitis Pigmentosa-12
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13198 SLC35B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC35B1 MGD MGI:1343133
Rattus norvegicus SLC35B1 RGD RGD:727783
Macaca mulatta SLC35B1 VGNC VGNC:77533
Canis familiaris SLC35B1 VGNC VGNC:46364
Bos taurus SLC35B1 VGNC VGNC:34823
Felis catus SLC35B1 VGNC VGNC:65324
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