2. Gene
  3. PTPN5 - protein tyrosine phosphatase non-receptor type 5 Gene

PTPN5 - protein tyrosine phosphatase non-receptor type 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白酪氨酸磷酸酶非受体 5 型

种属: Homo sapiens

同用名: STEP; STEP61; PTPSTEP

基因 ID: 84867 | 基因类型: protein coding

关于 PTPN5

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:18,727,928-18,792,721 (from NCBI)

This gene has 6 transcripts (splice variants), 202 orthologues and 35 paralogues. Biased expression in brain (RPKM 11.0), testis (RPKM 0.9) and 1 other tissue.

功能概要

启用磷酸酪氨酸残基结合活性。预测参与肽基-酪氨酸去磷酸化。预测作用于蛋白质去磷酸化的上游或内部。预测位于核质中。预计是膜的组成部分。阿尔茨海默病的生物标志物。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphotyrosine residue binding activity. Predicted to be involved in peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within protein dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be integral component of membrane. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]

PTPN5 基因产物(6)

mRNA Protein Name
NM_001039970.2 NP_001035059.1 tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278236.1 NP_001265165.1 tyrosine-protein phosphatase non-receptor type 5 isoform b
NM_001278238.2 NP_001265167.1 tyrosine-protein phosphatase non-receptor type 5 isoform c
NM_001278239.2 NP_001265168.1 tyrosine-protein phosphatase non-receptor type 5 isoform d
NM_006906.2 NP_008837.1 tyrosine-protein phosphatase non-receptor type 5 isoform a
NM_032781.4 NP_116170.3 tyrosine-protein phosphatase non-receptor type 5 isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphotyrosine residue binding IDA
IDA: 通过直接分析推断
16441242 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPN5 蛋白结构

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (324 - 552)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 565 a.a.
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 5

neural-specific protein-tyrosine phosphatase

PTPN5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PTPN5 P54829 TMEM201 Homo sapiens Q5SNT2-2
Validated Y2H
32296183
Intra PTPN5 P54829 SLC35B1 Homo sapiens P78383
Validated Y2H
32296183
Intra PTPN5 P54829 CLEC4G Homo sapiens Q6UXB4
Validated Y2H
32296183
Intra PTPN5 P54829 MARCHF5 Homo sapiens Q9NX47
Validated Y2H
32296183
Intra PTPN5 P54829 CXCL9 Homo sapiens Q07325
Y2H Prey Pooling
25416956
Intra PTPN5 P54829 CXCL9 Homo sapiens Q07325
Validated Y2H
25416956
Intra PTPN5 P54829 TERF1 Homo sapiens P54274
BiFC
21044950
Intra PTPN5 P54829 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra PTPN5 P54829 VTI1B Homo sapiens Q9UEU0
Y2H Array
31515488
Intra PTPN5 P54829 TMEM51 Homo sapiens Q9NW97
Y2H Prey Pooling
25416956
Intra PTPN5 P54829 TMEM51 Homo sapiens Q9NW97
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Viral Gastritis
Fragile X Syndrome

FXS

Martin-Bell Syndrome

Fraxa Syndrome

Marker X Syndrome

X-Linked Mental Retardation And Macroorchidism

Fragile X Mental Retardation Syndrome

Fra Syndrome

Mental Retardation, X-Linked, Associated With Marxq28

X-Linked Intellectual Disability And Macroorchidism

Frax Syndrome

Symptomatic Form Of Fragile X Syndrome In Female Carriers

Fragile-X Syndrome

Fraxe Syndrome
Phencyclidine Abuse

Pcp Abuse
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141800 MurA-IN-1 Inhibitor 99.32% 否
HY-RS11428 PTPN5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PTPN5 RGD RGD:3448
Macaca mulatta PTPN5 VGNC VGNC:76606
Canis familiaris PTPN5 VGNC VGNC:45178
Felis catus PTPN5 VGNC VGNC:69165
Mus musculus PTPN5 MGD MGI:97807
Bos taurus PTPN5 VGNC VGNC:33540
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