RAMP1 - receptor activity modifying protein 1 Gene

中文名称：受体活性修饰蛋白 1

种属: Homo sapiens

关于 RAMP1

功能概要

由该基因编码的蛋白质是单跨膜域蛋白质 RAMP 家族的成员，称为受体 (降钙素) 活性修饰蛋白 (RAMP) 。 RAMP 是 I 型跨膜蛋白，具有细胞外 N 末端和细胞质 C 末端。需要 RAMP 将降钙素受体样受体 (CRLR) 转运至质膜。 CRLR 是一种具有七个跨膜结构域的受体，可以作为降钙素基因相关肽 (CGRP) 受体或肾上腺髓质素受体发挥作用，具体取决于表达 RAMP 家族的哪些成员。在这种 (RAMP1) 蛋白存在的情况下，CRLR 充当 CGRP 受体。 RAMP1 蛋白参与 CGRP 受体向细胞表面的末端糖基化、成熟和呈递。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2015 年 4 月]

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (Calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an Adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP Receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP Receptor to the cell surface. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]