CALCRL - calcitonin receptor like receptor Gene

中文名称：降钙素受体样受体

种属: Homo sapiens

同用名: CRLR; CGRPR; LMPHM8

基因 ID: 10203 | 基因类型: protein coding

关于 CALCRL

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:187,341,964-187,448,252 (from NCBI)

This gene has 9 transcripts (splice variants), 148 orthologues, 42 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 41.7), fat (RPKM 35.2) and 20 other tissues.

功能概要

启用肾上腺髓质素结合活动；肾上腺髓质素受体活性；和降钙素基因相关的肽受体活性。参与多个过程，包括 G 蛋白偶联受体信号通路；细胞对蔗糖刺激的反应；和受体内化。位于内质网；核内体；和溶酶体。部分 CGRP 受体复合物和肾上腺髓质素受体复合物。与质膜共定位。与遗传性淋巴水肿有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables Adrenomedullin binding activity; Adrenomedullin receptor activity; and Calcitonin gene-related peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to sucrose stimulus; and receptor internalization. Located in endoplasmic reticulum; endosome; and lysosome. Part of CGRP Receptor complex and Adrenomedullin receptor complex. Colocalizes with plasma membrane. Implicated in hereditary lymphedema. [provided by Alliance of Genome Resources, Apr 2022]

CALCRL 基因产物(4)

mRNA	Protein	Name
NM_001271751.2	NP_001258680.1	calcitonin gene-related peptide type 1 receptor precursor
NM_001369434.1	NP_001356363.1	calcitonin gene-related peptide type 1 receptor precursor
NM_001369435.1	NP_001356364.1	calcitonin gene-related peptide type 1 receptor precursor
NM_005795.6	NP_005786.1	calcitonin gene-related peptide type 1 receptor precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables adrenomedullin binding	IPI IPI: 通过物理相互作用推断	20074556	GOA
enables adrenomedullin receptor activity	IPI IPI: 通过物理相互作用推断	9620797	GOA
enables calcitonin gene-related peptide receptor activity	IPI IPI: 通过物理相互作用推断	9620797	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16293613	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IPI IPI: 通过物理相互作用推断	9620797	GOA
involved in adrenomedullin receptor signaling pathway	IPI IPI: 通过物理相互作用推断	9620797	GOA
involved in angiogenesis	IDA IDA: 通过直接分析推断	20596610	GOA
involved in calcitonin gene-related peptide receptor signaling pathway	IPI IPI: 通过物理相互作用推断	9620797	GOA
involved in calcium ion transport	IDA IDA: 通过直接分析推断	10882736	GOA
involved in cellular response to sucrose stimulus	IDA IDA: 通过直接分析推断	10882736	GOA
involved in protein transport	IDA IDA: 通过直接分析推断	9620797	GOA
involved in receptor internalization	IDA IDA: 通过直接分析推断	10882736	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CGRP receptor complex	IDA IDA: 通过直接分析推断	9620797	GOA
part of adrenomedullin receptor complex	IDA IDA: 通过直接分析推断	9620797	GOA
part of adrenomedullin receptor complex	IPI IPI: 通过物理相互作用推断	22102369	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	10882736	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	10882736	GOA
located in endosome	IDA IDA: 通过直接分析推断	10882736	GOA
located in lysosome	IDA IDA: 通过直接分析推断	10882736	GOA
colocalizes with plasma membrane	IDA IDA: 通过直接分析推断	9620797	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10882736	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CALCRL 蛋白结构

HRM

7tm_2

0
100
200
300
400
461 a.a.

蛋白主名

其他名称

calcitonin gene-related peptide type 1 receptor

CGRP type 1 receptor

CALCRL 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CALCRL	Q16602	RAMP2	Homo sapiens	O60895	GMS	22102369
种属内	CALCRL	Q16602	RAMP2	Homo sapiens	O60895	Electrophoresis	22102369
种属内	CALCRL	Q16602	RAMP1	Homo sapiens	O60894	X-Ray Diffraction	20826335
种属内	CALCRL	Q16602	RAMP1	Homo sapiens	O60894	GMS	20826335
种属内	CALCRL	Q16602	RAMP1	Homo sapiens	O60894	Confocal	16293613
种属内	CALCRL	Q16602	CALCA	Homo sapiens	P06881	SPA	23597562

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Lymphatic Malformation 8

LMPHM8

Hereditary Lymphedema

Milroy Disease

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Immune Hydrops Fetalis

Ihf	Immune Hf
Immune Fetal Edema	Immune Fetal Hydrops

Primary Lymphedema

Lymphedema Primary

Acute Closed-Angle Glaucoma

Acute Angle-Closure Glaucoma

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Leopard Syndrome 2

LPRD2	Noonan Syndrome With Multiple Lentigines 2
Leopard Syndrome, Type 2

Cartilage Cancer

Chondrogenic Neoplasm

Hypotrichosis-Lymphedema-Telangiectasia Syndrome

HLTS	Hypotrichosis Lymphedema Telangiectasia Syndrome
Hypotrichosis-Lymphedema-Telangiectasia-Membranoproliferative Glomerulonephritis Syndrome	Hypotrichosis-Lymphedema-Telangiectasia-Renal Defect Syndrome

Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly

Asperger Syndrome

Asperger Disorder

Asperger Syndrome, Susceptibility To

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01835	CALCRL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CALCRL	MGD	MGI:1926944
Rattus norvegicus	CALCRL	RGD	RGD:2255
Canis familiaris	CALCRL	VGNC	VGNC:38665
Felis catus	CALCRL	VGNC	VGNC:107492
Bos taurus	CALCRL	VGNC	VGNC:26705
Macaca mulatta	CALCRL	VGNC	VGNC:70573

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CALCRL - calcitonin receptor like receptor Gene

关于 CALCRL

功能概要

CALCRL 基因产物(4)

CALCRL 蛋白结构

CALCRL 蛋白互作信息

关联疾病

直系同源

热门区域

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CALCRL - calcitonin receptor like receptor Gene

关于 CALCRL

功能概要

CALCRL 基因产物(4)

CALCRL 蛋白结构

CALCRL 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z