EFS - embryonal Fyn-associated substrate Gene

中文名称：胚胎 Fyn 相关底物

种属: Homo sapiens

同用名: SIN; CAS3; EFS1; EFS2; HEFS; CASS3

关于 EFS

功能概要

由该基因编码的蛋白质是 CAS (CRK 相关底物) 衔接蛋白家族的成员，通常用作组装较大信号复合物的支架。这些复合物在细胞表面形成，整合素结合导致 CAS 蛋白随后发生磷酸化。 Src 家族激酶的额外结合会导致 CAS 过度磷酸化，并为 CRK 和其他引起肌动蛋白细胞骨架重组的蛋白质创建结合位点。该基因在整合素介导的细胞附着、扩散和迁移中发挥作用，还在正常和恶性细胞转化中发挥作用。这种广泛表达的基因已被证明在神经突生长中发挥作用，其在胸腺和淋巴细胞中的表达对于 T 细胞成熟和免疫自身耐受的发展很重要。该基因的可变剪接导致编码不同亚型的多个转录变体。[RefSeq 提供，2020 年 7 月]

The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where Integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of Src family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin Cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]