NUP155 - nucleoporin 155 Gene

中文名称：核孔蛋白 155

种属: Homo sapiens

同用名: N155; ATFB15

基因 ID: 9631 | 基因类型: protein coding

关于 NUP155

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:37,288,137-37,371,106 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 44.4), bone marrow (RPKM 5.5) and 19 other tissues.

功能概要

核孔蛋白是在核孔复合体 (NPC) 的组装和功能中发挥重要作用的蛋白质，核孔复合体调节大分子穿过核膜 (NE) 的运动。由该基因编码的蛋白质在 NE 囊泡的融合和双膜 NE 的形成中起作用。该蛋白质还可能参与心脏生理学，并可能与心房颤动的发病机制有关。可变剪接导致该基因的多个转录变体。与该基因相关的假基因位于 6 号染色体上。[RefSeq 提供，2013 年 5 月]

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

NUP155 基因产物(3)

mRNA	Protein	Name
NM_001278312.2	NP_001265241.1	nuclear pore complex protein Nup155 isoform 3
NM_004298.4	NP_004289.1	nuclear pore complex protein Nup155 isoform 2
NM_153485.3	NP_705618.1	nuclear pore complex protein Nup155 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within nuclear envelope organization	IDA IDA: 通过直接分析推断	19070573	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nuclear envelope	IDA IDA: 通过直接分析推断	19070573	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP155 蛋白结构

Nucleoporin_N

Nucleoporin_C

0
300
600
900
1200
1391 a.a.

蛋白主名

其他名称

nuclear pore complex protein Nup155

155 kDa nucleoporin

NUP155 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Anti Bait CoIP	30488537
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Confocal	30488537
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Pull Down	30488537

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Atrial Fibrillation, Familial, 15

ATFB15	Atrial Fibrillation 15
Fibrillation, Atrial, Familial, Type 15

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

Atrial Fibrillation

A-Fib	Fibrillation, Atrial
Af - [Atrial Fibrillation]	Rapid Atrial Fibrillation
A Fib - [Atrial Fibrillation]

Lethal Congenital Contracture Syndrome 1

LCCS1	Multiple Contracture Syndrome, Finnish Type
Lccs	Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures
Lethal Congenital Contracture Syndrome Type 1	Herva Disease
Multiple Contracture Syndrome Finnish Type	Contracture Syndrome, Lethal, Congenital, Type 1

Anterior Horn Cell Disease

Lethal Congenital Contracture Syndrome

Lccs	Lethal Congenital Contracture Syndrome 1

Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome	Triple-A Syndrome
Achalasia-Addisonianism-Alacrimia Syndrome	Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder
Triple A Syndrome	Aaa Syndrome
AAAS	Glucocorticoid Deficiency With Achalasia
Glucocorticoid Deficiency And Achalasia	Addisonian-Achalasia Syndrome
Hypoadrenalism With Achalasia	Alacrima-Achalasia-Addisonianism
Aaa	Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima
Achalasia Addisonianism Alacrimia Syndrome	Achalasia Alacrima Syndrome
Addisonian Achalasia Syndrome	Achalasia-Addisonian Syndrome
Achalasia-Alacrima Syndrome	2a Syndrome
3a Syndrome	4a Syndrome
Adrenal Insufficiency-Achalasia-Alacrima Syndrome	Double A Syndrome
Quaternary A Syndrome	Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima
Allgrove'S Syndrome	Adrenal Gland Hypofunction
Adrenal Cortical Hypofunction

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09686	NUP155 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	NUP155	VGNC	VGNC:44046
Macaca mulatta	NUP155	VGNC	VGNC:84456
Bos taurus	NUP155	VGNC	VGNC:32352
Mus musculus	NUP155	MGD	MGI:2181182
Felis catus	NUP155	VGNC	VGNC:102275
Rattus norvegicus	NUP155	RGD	RGD:621199

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NUP155 - nucleoporin 155 Gene

关于 NUP155

功能概要

NUP155 基因产物(3)

NUP155 蛋白结构

NUP155 蛋白互作信息

关联疾病

直系同源

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NUP155 - nucleoporin 155 Gene

关于 NUP155

功能概要

NUP155 基因产物(3)

NUP155 蛋白结构

NUP155 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z