2. Gene
  3. LYPLA1 - lysophospholipase 1 Gene

LYPLA1 - lysophospholipase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶血磷脂酶 1

种属: Homo sapiens

同用名: APT1; LPL1; APT-1; LPL-I; hAPT1

基因 ID: 10434 | 基因类型: protein coding

关于 LYPLA1

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:54,046,367-54,101,947 (from NCBI)

This gene has 15 transcripts (splice variants), 230 orthologues and 2 paralogues. Ubiquitous expression in urinary bladder (RPKM 38.7), testis (RPKM 35.4) and 25 other tissues.

功能概要

该基因编码 alpha/beta 水解酶超家族的成员。编码的蛋白质作为同源二聚体发挥作用，表现出脱棕榈酰化和溶血磷脂酶活性，并且可能参与 Ras 定位和信号传导。交替剪接导致多个转录本变体。该基因的假基因已在 4、6 和 7 号染色体上定义。[RefSeq 提供，2013 年 7 月]

This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]

LYPLA1 基因产物(6)

mRNA Protein Name
NM_001279356.2 NP_001266285.1 acyl-protein thioesterase 1 isoform 2
NM_001279357.2 NP_001266286.1 acyl-protein thioesterase 1 isoform 3
NM_001279358.2 NP_001266287.1 acyl-protein thioesterase 1 isoform 4
NM_001279359.2 NP_001266288.1 acyl-protein thioesterase 1 isoform 5
NM_001279360.2 NP_001266289.1 acyl-protein thioesterase 1 isoform 6
NM_006330.4 NP_006321.1 acyl-protein thioesterase 1 isoform 1

LYPLA1 蛋白结构

Abhydrolase_2

Abhydrolase_2: Phospholipase/Carboxylesterase (11 - 225)

  • 0
  • 100
  • 200
  • 230 a.a.
蛋白主名 其他名称

acyl-protein thioesterase 1

lysoPLA I

LYPLA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LYPLA1 O75608 SFMBT2 Homo sapiens Q5VUG0
Y2H Prey Pooling
32296183
种属内
LYPLA1 O75608 SFMBT2 Homo sapiens Q5VUG0
Validated Y2H
32296183
种属内
LYPLA1 O75608 SFMBT2 Homo sapiens Q5VUG0
Y2H Array
32296183
种属内
LYPLA1 O75608 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
种属内
LYPLA1 O75608 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
种属内
LYPLA1 O75608 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LYPLA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7539 APT-1/LYPLA1 Protein, Human (His) O75608 (M1-D230) ≥95%

LYPLA1 抗体

目录号 产品名 应用 反应物种
HY-P82452 Lysophospholipase 1 Antibody (YA2197) WB, ICC/IF, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis

Batten Disease

Ncl

Neuronal Ceroid-Lipofuscinoses

Lipofuscinosis, Ceroid, Neuronal

Juvenile Neuronal Ceroid Lipofuscinosis

Cerebromacular Dystrophy

Cerebromacular Degeneration

Ceroid-Lipofuscinosis

Ncl - [Neuronal Ceroid Lipofuscinosis]

Amaurotic Familial Idiocy

Amaurotic Idiocy

Amaurotic Idiot

Neuronal Lipofuscinosis

Pigmentary Retinal Lipoid Neuronal Heredodegeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100736 ML348 Inhibitor 99.96% 否
HY-128035 ML-211 Inhibitor 98.06% 否
HY-RS07921 LYPLA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LYPLA1 VGNC VGNC:84014
Mus musculus LYPLA1 MGD MGI:1344588
Canis familiaris LYPLA1 VGNC VGNC:42890
Rattus norvegicus LYPLA1 RGD RGD:3025
Felis catus LYPLA1 VGNC VGNC:97489
Others LYPLA1 NCBI
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