2. Gene
  3. SMC2 - structural maintenance of chromosomes 2 Gene

SMC2 - structural maintenance of chromosomes 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：2 号染色体的结构维护

种属: Homo sapiens

同用名: CAPE; CAP-E; SMC-2; SMC2L1

基因 ID: 10592 | 基因类型: protein coding

关于 SMC2

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:104,088,263-104,141,419 (from NCBI)

This gene has 5 transcripts (splice variants), 219 orthologues and 7 paralogues. Ubiquitous expression in lymph node (RPKM 6.5), testis (RPKM 6.0) and 24 other tissues.

功能概要

预测启用 ATP 绑定活动；染色质结合活性；和单链 DNA 结合活性。参与有丝分裂染色体浓缩。位于浓缩染色体；细胞质；和核腔。凝缩蛋白复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable ATP binding activity; chromatin binding activity; and single-stranded DNA binding activity. Involved in mitotic chromosome condensation. Located in condensed chromosome; cytoplasm; and nuclear lumen. Part of condensin complex. [provided by Alliance of Genome Resources, Apr 2022]

SMC2 基因产物(4)

mRNA Protein Name
NM_001042550.2 NP_001036015.1 structural maintenance of chromosomes protein 2
NM_001042551.2 NP_001036016.1 structural maintenance of chromosomes protein 2
NM_001265602.2 NP_001252531.1 structural maintenance of chromosomes protein 2
NM_006444.3 NP_006435.2 structural maintenance of chromosomes protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9789013 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mitotic chromosome condensation IDA
IDA: 通过直接分析推断
11136719 GOA
involved in positive regulation of chromosome condensation IDA
IDA: 通过直接分析推断
17268547 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in condensed chromosome IDA
IDA: 通过直接分析推断
12589063 GOA
part of condensin complex IDA
IDA: 通过直接分析推断
9789013 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
10958694 GOA
located in nuclear chromosome IDA
IDA: 通过直接分析推断
10958694 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12589063 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMC2 蛋白结构

SMC_N

SMC_N: RecF/RecN/SMC N terminal domain (2 - 671)

SMC_hinge

SMC_hinge: SMC proteins Flexible Hinge Domain (522 - 640)

SMC_N

SMC_N: RecF/RecN/SMC N terminal domain (862 - 1163)

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  • 1197 a.a.
蛋白主名 其他名称

structural maintenance of chromosomes protein 2

SMC protein 2

关联疾病

疾病名称 别名
Pleural Empyema

Empyema

Pyothorax

Empyema, Pleural

Abscess Of Pleural Cavity

Abscess Of Thorax

Empyema Of Pleura

Empyema Of Pleura Without Fistula

Empyema With Fistula

Empyema With No Fistula

Empyema With Pleural Fistula

Empyema Without Mention Of Fistula

Empyema, Chest

Lung Empyema

Pleural Empyema With Fistula

Pleural Empyema With No Fistula

Purulent Pleurisy

Purulent Pleuritis

Thorax Abscess

Pyopneumothorax
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13418 SMC2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SMC2 VGNC VGNC:34999
Mus musculus SMC2 MGD MGI:106067
Rattus norvegicus SMC2 RGD RGD:1305227
Macaca mulatta SMC2 VGNC VGNC:77698
Canis familiaris SMC2 VGNC VGNC:46543
Felis catus SMC2 VGNC VGNC:65476
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