RGS14 - regulator of G protein signaling 14 Gene

中文名称：G 蛋白信号调节器 14

种属: Homo sapiens

关于 RGS14

功能概要

该基因编码 G 蛋白信号家族的调节剂成员。该蛋白包含一个 RGS 结构域、两个 Raf 样 Ras 结合结构域 (RBD) 和一个 GoLoco 结构域。该蛋白通过其 GoLoco 结构域与特定类型的活化 GTP 结合 G α 亚基结合，从而减弱 G 蛋白的信号活性。作为 GTP 酶激活蛋白 (GAP) ，该蛋白可提高 GTP 向 GDP 的转化率。这种水解允许 G α 亚基结合 G β/γ 亚基异二聚体，形成无活性的 G 蛋白异三聚体，从而终止信号。已观察到该基因的替代转录剪接变体，但尚未彻底表征。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]