2. Gene
  3. GNAI1 - G protein subunit alpha i1 Gene

GNAI1 - G protein subunit alpha i1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白亚基αi1

种属: Homo sapiens

同用名: Gi; HG1B; NEDHISB

基因 ID: 2770 | 基因类型: protein coding

关于 GNAI1

Cytogenetic location: 7q21.11 Genomic coordinates (GRCh38): 7:80,134,831-80,226,181 (from NCBI)

This gene has 32 transcripts (splice variants), 224 orthologues, 15 paralogues and is associated with 2 phenotypes. Ubiquitous expression in fat (RPKM 39.3), brain (RPKM 28.1) and 22 other tissues.

功能概要

鸟嘌呤核苷酸结合蛋白是由 α、β 和 γ 亚基组成的异源三聚体信号转导分子。 α 亚基结合鸟嘌呤核苷酸，可水解 GTP，并可与其他蛋白质相互作用。该基因编码的蛋白质代表抑制复合物的α亚基。编码的蛋白质是通过抑制腺苷酸环化酶响应 β-肾上腺素能信号的复合物的一部分。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2012 年 1 月]

Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting Adenylate Cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GNAI1 基因产物(2)

mRNA Protein Name
NM_001256414.2 NP_001243343.1 guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 2
NM_002069.6 NP_002060.4 guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D2 dopamine receptor binding IPI
IPI: 通过物理相互作用推断
33571431 GOA
enables G protein activity IDA
IDA: 通过直接分析推断
16204467 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
34685729 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
8774883 GOA
enables adenylate cyclase regulator activity IDA
IDA: 通过直接分析推断
33762731 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15537540 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell migration IDA
IDA: 通过直接分析推断
20829352 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
16204467 GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA
IDA: 通过直接分析推断
33762731 GOA
involved in cell division IMP
IMP: 通过突变表型推断
17635935 GOA
involved in positive regulation of cholesterol biosynthetic process IDA
IDA: 通过直接分析推断
38503280 GOA
involved in positive regulation of protein localization to cell cortex IMP
IMP: 通过突变表型推断
22327364 GOA
involved in regulation of mitotic spindle organization IMP
IMP: 通过突变表型推断
23027904 GOA
involved in response to prostaglandin E IDA
IDA: 通过直接分析推断
16204467 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell cortex IDA
IDA: 通过直接分析推断
22327364 GOA
located in centrosome IDA
IDA: 通过直接分析推断
17635935 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17635935 GOA
is active in cytosol IDA
IDA: 通过直接分析推断
17635935 GOA
part of heterotrimeric G-protein complex IDA
IDA: 通过直接分析推断
33762731 GOA
located in midbody IDA
IDA: 通过直接分析推断
17635935 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17635935 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GNAI1 蛋白结构

G-alpha

G-alpha: G-protein alpha subunit (6 - 343)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
蛋白主名 其他名称

guanine nucleotide-binding protein G(i) subunit alpha-1

Gi1 protein alpha subunit

GNAI1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra GNAI1 P63096 PCP2 Homo sapiens Q8IVA1
Y2H Prey Pooling
32296183
Intra GNAI1 P63096 PCP2 Homo sapiens Q8IVA1
Validated Y2H
32296183
Intra GNAI1 P63096 PCP2 Homo sapiens Q8IVA1
Y2H Array
32296183
Intra GNAI1 P63096 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32296183
Intra GNAI1 P63096 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
25416956
Intra GNAI1 P63096 NUMA1 Homo sapiens Q14980
Anti Tag CoIP
15537540
Intra GNAI1 P63096 NUMA1 Homo sapiens Q14980
IF
15537540
Intra GNAI1 P63096 GPSM2 Homo sapiens P81274
Anti Tag CoIP
15537540
Intra GNAI1 P63096 GPSM2 Homo sapiens P81274
IF
15537540
Intra GNAI1 P63096 RIC8A Homo sapiens Q9NPQ8
Anti Tag CoIP
33961781
Intra GNAI1 P63096 RGS14 Homo sapiens O43566
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Hypotonia, Impaired Speech, And Behavioral Abnormalities

NEDHISB
Cholera

Vibrio Cholerae Infection

Cholera - Vibrio Cholerae

Cholera Due To Vibrio Cholerae

Vibrio Cholerae

Cholera Syndrome

Asiatic Cholera

Epidemic Cholera
Pertussis

Whooping Cough

Bordetella Infections

Bordetella Infection

Bordetella Pertussis Infection

Wc - Whooping Cough

Whooping Cough Due To Unspecified Organism

Bordetellosis

Tussis Convulsiva

Whooping Cough, Unspecified Organism

Wc - [Whooping Cough]

Whooping Cough Due To B. Parapertussis

Infection Due To Bordetella Parapertussis
Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary

Congenital Essential Nyctalopia

Oguchi Disease

Blindness, Night, Stationary, Congenital
Night Blindness

Nyctalopia
Pilomyxoid Astrocytoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05534 GNAI1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GNAI1 MGD MGI:95771
Canis familiaris GNAI1 VGNC VGNC:41301
Bos taurus GNAI1 VGNC VGNC:29449
Felis catus GNAI1 VGNC VGNC:62616
Rattus norvegicus GNAI1 RGD RGD:2713
Macaca mulatta GNAI1 VGNC VGNC:73089
Others GNAI1 NCBI
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