2. Gene
  3. IGF2BP2 - insulin like growth factor 2 mRNA binding protein 2 Gene

IGF2BP2 - insulin like growth factor 2 mRNA binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胰岛素样生长因子 2 mRNA 结合蛋白 2

种属: Homo sapiens

同用名: IMP2; IMP-2; VICKZ2

基因 ID: 10644 | 基因类型: protein coding

关于 IGF2BP2

Cytogenetic location: 3q27.2 Genomic coordinates (GRCh38): 3:185,643,130-185,825,042 (from NCBI)

This gene has 11 transcripts (splice variants), 222 orthologues, 12 paralogues and is associated with 64 phenotypes. Broad expression in placenta (RPKM 4.8), colon (RPKM 4.7) and 24 other tissues.

功能概要

该基因编码的蛋白质结合胰岛素样生长因子 2 (IGF2) mRNA 的 5' UTR 并调节其翻译。它在新陈代谢中起着重要作用，该基因的变异与糖尿病的易感性有关。选择性剪接和启动子使用会导致多种转录本变体。在几条染色体上发现了相关的假基因。[RefSeq 提供，2016 年 9 月]

This gene encodes a protein that binds the 5' UTR of insulin-like growth factor 2 (IGF2) mRNA and regulates its translation. It plays an important role in metabolism and variation in this gene is associated with susceptibility to diabetes. Alternative splicing and promoter usage results in multiple transcript variants. Related pseudogenes are found on several chromosomes. [provided by RefSeq, Sep 2016]

IGF2BP2 基因产物(7)

mRNA Protein Name
NM_001007225.3 NP_001007226.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform b
NM_001291869.3 NP_001278798.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform c
NM_001291872.3 NP_001278801.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform d
NM_001291873.3 NP_001278802.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform e
NM_001291874.3 NP_001278803.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform f
NM_001291875.3 NP_001278804.1 insulin-like growth factor 2 mRNA-binding protein 2 isoform g
NM_006548.6 NP_006539.3 insulin-like growth factor 2 mRNA-binding protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: 通过直接分析推断
29476152 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
20080952 GOA
enables mRNA 5'-UTR binding IDA
IDA: 通过直接分析推断
9891060 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12674497 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CRD-mediated mRNA stabilization IDA
IDA: 通过直接分析推断
29476152 GOA
involved in RNA stabilization IMP
IMP: 通过突变表型推断
36354136 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
29476152 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
15618018 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
29476152 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
15618018 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15618018 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IGF2BP2 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (5 - 62)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (86 - 148)

KH_1

KH_1: KH domain (196 - 258)

KH_1

KH_1: KH domain (278 - 338)

KH_1

KH_1: KH domain (432 - 491)

KH_1

KH_1: KH domain (512 - 575)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
蛋白主名 其他名称

insulin-like growth factor 2 mRNA-binding protein 2

IGF-II mRNA-binding protein 2

IGF2BP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IGF2BP2 Q9Y6M1 DYRK1A Homo sapiens Q13627
Anti Bait CoIP
36950384
种属内
IGF2BP2 Q9Y6M1 RBM3 Homo sapiens P98179
Anti Bait CoIP
31484925
种属内
IGF2BP2 Q9Y6M1 RBM3 Homo sapiens P98179
Anti Tag CoIP
31484925
种属内
IGF2BP2 Q9Y6M1 HNRNPD Homo sapiens Q14103-4
Pull Down
12674497
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IGF2BP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70950 IGF2BP2 Protein, Human (T7-His) Q9Y6M1-2 (M1-T220) ≥95%
HY-P74850 IGF2BP2 Protein, Human (sf9, His-GST) Q9Y6M1-2 (M1-K599) ≥95%

关联疾病

疾病名称 别名
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Wolfram Syndrome 1

WFS1

Didmoad

Wfs

Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

Wolfram Syndrome
Diabetes Mellitus

Diabetes
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153274 CWI1-2 Inducer 98.00% 否
HY-153274A CWI1-2 hydrochloride Inducer 98.27% 否
HY-RS06620 IGF2BP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus IGF2BP2 MGD MGI:1890358
Felis catus IGF2BP2 VGNC VGNC:62889
Macaca mulatta IGF2BP2 VGNC VGNC:84165
Canis familiaris IGF2BP2 VGNC VGNC:41899
Bos taurus IGF2BP2 VGNC VGNC:30080
Rattus norvegicus IGF2BP2 RGD RGD:1305614
Others IGF2BP2 NCBI
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