2. Gene
  3. PLK2 - polo like kinase 2 Gene

PLK2 - polo like kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：马球样激酶 2

种属: Homo sapiens

同用名: SNK; hSNK; hPlk2

基因 ID: 10769 | 基因类型: protein coding

关于 PLK2

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:58,453,982-58,460,086 (from NCBI)

This gene has 15 transcripts (splice variants), 221 orthologues and 4 paralogues. Broad expression in spleen (RPKM 41.3), placenta (RPKM 28.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质是在正常细胞分裂中起作用的丝氨酸/苏氨酸蛋白激酶 polo 家族的成员。该基因在睾丸、脾脏和胎儿组织中表达最丰富，其表达可被血清诱导，表明它也可能在经历快速细胞分裂的细胞中发挥重要作用。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene is a member of the polo family of serine/threonine protein kinases that have a role in normal cell division. This gene is most abundantly expressed in testis, spleen and fetal tissues, and its expression is inducible by serum, suggesting that it may also play an important role in cells undergoing rapid cell division. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

PLK2 基因产物(2)

mRNA Protein Name
NM_001252226.2 NP_001239155.1 serine/threonine-protein kinase PLK2 isoform 2
NM_006622.4 NP_006613.2 serine/threonine-protein kinase PLK2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent protein binding IDA
IDA: 通过直接分析推断
23983262 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20352051 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
19001868 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
15242618 GOA
involved in mitotic spindle organization IDA
IDA: 通过直接分析推断
19001868 GOA
involved in peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
23983262 GOA
involved in positive regulation of autophagy IDA
IDA: 通过直接分析推断
23983262 GOA
involved in positive regulation of protein catabolic process IDA
IDA: 通过直接分析推断
23983262 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
20352051 GOA
involved in regulation of centriole replication IDA
IDA: 通过直接分析推断
19001868 GOA
involved in regulation of centriole replication IMP
IMP: 通过突变表型推断
15242618 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centriole IDA
IDA: 通过直接分析推断
19001868 GOA
located in centrosome IDA
IDA: 通过直接分析推断
15242618 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23983262 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (83 - 334)

POLO_box

POLO_box: POLO box duplicated region (510 - 573)

POLO_box

POLO_box: POLO box duplicated region (607 - 676)

  • 0
  • 200
  • 400
  • 600
  • 685 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PLK2

PLK-2

serine/threonine-protein kinase SNK

serum-inducible kinase

PLK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLK2 Q9NYY3 CENPJ Homo sapiens Q9HC77
Protein Kinase Assay
20531387
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2

Temporal Epilepsy, Familial

ETL2

Ftle

Epilepsy, Familial Temporal Lobe

Familial Temporal Lobe Epilepsy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12137 Volasertib Inhibitor 99.41% 是
HY-12137A Volasertib trihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (7)
目录号 产品名 作用方式
纯度 Phase
HY-12037A Rigosertib Inhibitor 99.01% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100789 ON1231320 Inhibitor 99.24% 否
HY-108597 TC-S 7005 Inhibitor 99.68% 否
HY-12134 Poloxin Inhibitor 98.01% 否
HY-149100 PLK1-IN-6 Inhibitor / 否
HY-115589 YLT-11 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLK2 RGD RGD:620760
Macaca mulatta PLK2 VGNC VGNC:76076
Canis familiaris PLK2 VGNC VGNC:44696
Mus musculus PLK2 MGD MGI:1099790
Bos taurus PLK2 VGNC VGNC:33034
Felis catus PLK2 VGNC VGNC:64244
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