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  2. RAB10 - RAB10, member RAS oncogene family Gene

RAB10 - RAB10, member RAS oncogene family Gene

中文名称:RAB10,RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 10890 | 基因类型: protein coding

关于 RAB10

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:26,033,285-26,137,454 (from NCBI)

This gene has 4 transcripts (splice variants), 215 orthologues and 68 paralogues. Ubiquitous expression in esophagus (RPKM 102.3), colon (RPKM 40.9) and 25 other tissues.

功能概要

RAB10 属于小 GTP 酶的 Ras (参见 HRAS;MIM 190020) 超家族。 RAB 蛋白定位于胞吐和胞内隔室并调节细胞内囊泡运输 (Bao 等人,1998 [PubMed 9918381]) 。[OMIM 提供,2009 年 3 月]

RAB10 belongs to the Ras (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]

RAB10 基因产物(1)

mRNA Protein Name
NM_016131.5 NP_057215.3 ras-related protein Rab-10
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IDA
IDA: 通过直接分析推断
20937701 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
20937701 GOA
enables myosin V binding IPI
IPI: 通过物理相互作用推断
22908308 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antigen processing and presentation IMP
IMP: 通过突变表型推断
19717423 GOA
involved in endoplasmic reticulum tubular network organization IMP
IMP: 通过突变表型推断
23263280 GOA
involved in endosomal transport IMP
IMP: 通过突变表型推断
16641372 GOA
involved in establishment of protein localization to endoplasmic reticulum membrane IMP
IMP: 通过突变表型推断
23263280 GOA
involved in establishment of protein localization to membrane IMP
IMP: 通过突变表型推断
24006491 GOA
involved in regulated exocytosis IMP
IMP: 通过突变表型推断
2732579 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
23263280 GOA
located in cilium IDA
IDA: 通过直接分析推断
20576682 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
23263280 GOA
located in endoplasmic reticulum tubular network IDA
IDA: 通过直接分析推断
23263280 GOA
located in endosome IDA
IDA: 通过直接分析推断
20576682 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
32344433 GOA
located in exocytic vesicle IDA
IDA: 通过直接分析推断
18504258 GOA
located in insulin-responsive compartment IDA
IDA: 通过直接分析推断
22908308 GOA
colocalizes with plasma membrane IDA
IDA: 通过直接分析推断
22908308 GOA
located in recycling endosome IDA
IDA: 通过直接分析推断
16641372 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAB10 蛋白结构

Ras

Ras: Ras family (11 - 171)

  • 0
  • 100
  • 200 a.a.
蛋白主名 其他名称

ras-related protein Rab-10

GTP-binding protein RAB10

RAB10 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB10 P61026 RAB39A Homo sapiens Q14964 30021884
种属内
RAB10 P61026 RAB39A Homo sapiens Q14964 26824392
种属内
RAB10 P61026 LRRK2 Homo sapiens Q5S007 26824392
种属内
RAB10 P61026 RILPL2 Homo sapiens Q969X0 32017888
种属内
RAB10 P61026 OPTN Homo sapiens Q96CV9 25416956
种属内
RAB10 P61026 OPTN Homo sapiens Q96CV9 25416956
种属内
RAB10 P61026 OPTN Homo sapiens Q96CV9 25416956
种属内
RAB10 P61026 PPM1H Homo sapiens Q9ULR3 31663853
种属间: 跨种属相互作用 种属内: 同种属相互作用

RAB10 抗体

目录号 产品名 应用 反应物种
HY-P82044 Rab10 Antibody (YA1789) WB, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Carpenter Syndrome 1

Carpenter Syndrome

Acrocephalopolysyndactyly Type Ii

Acps Ii

CRPT1

Acrocephalopolysyndactyly Type 2

Acrocephalosyndactyly, Type Ii

Acrocephalopolysyndactyly 2

Acps2

Acps 2

Type Ii Acrocephalosyndactyly

Carpenter Syndrome, Type 1

Apert-Crouzon Disease

Microvillus Inclusion Disease

Congenital Microvillous Atrophy

Intractable Diarrhea Of Infancy

Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities

Davidson Disease

Microvillous Inclusion Disease

Congenital Microvillus Atrophy

Mvid

Diarrhea 2 With Microvillus Atrophy

Mvd

Congenital Familial Protracted Diarrhea

Davidson'S Disease

Familial Enteropathy, Microvillus

Microvillus Atrophy, Congenital

Congenital Enteropathy

Familial Protracted Enteropathy

Microvillous Atrophy

Microvillus Atrophy With Diarrhea 2

Idi

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Warburg Micro Syndrome 1

Warburg Micro Syndrome

Micro Syndrome

Warbm

WARBM1

Warburg Sjo Fledelius Syndrome

Warburg-Sjo-Fledelius Syndrome

Micro Syndrome 1

Microcephaly, Microcornea, Congenital Cataract, Intellectual Disability, Optic Atrophy And Hypogenitalism

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RAB10 VGNC VGNC:106202
Rattus norvegicus RAB10 RGD RGD:620879
Canis familiaris RAB10 VGNC VGNC:45247
Felis catus RAB10 VGNC VGNC:81163
Mus musculus RAB10 MGD MGI:105066
Bos taurus RAB10 VGNC VGNC:33613
Others RAB10 NCBI