1. Gene
  2. RILPL2 - Rab interacting lysosomal protein like 2 Gene

RILPL2 - Rab interacting lysosomal protein like 2 Gene

中文名称:Rab 相互作用溶酶体蛋白 2

种属: Homo sapiens

同用名: RLP2

基因 ID: 196383 | 基因类型: protein coding

关于 RILPL2

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:123,409,306-123,436,684 (from NCBI)

This gene has 1 transcript (splice variant), 203 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 15.2), thyroid (RPKM 7.3) and 24 other tissues.

功能概要

该基因编码的蛋白质包含与 rab 相互作用的溶酶体蛋白样结构域。该蛋白可能参与调节溶酶体形态。这种蛋白质也可能是丙型肝炎病毒的靶标并有助于病毒复制。交替剪接导致多个转录本变体。[RefSeq 提供,2015 年 1 月]

This gene encodes a protein that contains a rab-interacting lysosomal protein-like domain. This protein may be involved in regulating lysosome morphology. This protein may also be a target for the Hepatitis C virus and assist in viral replication. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RILPL2 基因产物(1)

mRNA Protein Name
NM_145058.3 NP_659495.1 RILP-like protein 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
29125462 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RILPL2 蛋白结构

RILP

RILP: Rab interacting lysosomal protein (134 - 189)

  • 0
  • 100
  • 211 a.a.
蛋白主名 其他名称

RILP-like protein 2

p40phox-binding protein

RILPL2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RILPL2 Q969X0 RILPL2 Homo sapiens Q969X0
Y2H Pooling
16189514
种属内
RILPL2 Q969X0 RAB8A Homo sapiens P61006
Anti Tag CoIP
29125462
种属内
RILPL2 Q969X0 RILPL2 Homo sapiens Q969X0
GMS
32017888
种属内
RILPL2 Q969X0 RILPL2 Homo sapiens Q969X0
Pull Down
16189514
种属内
RILPL2 Q969X0 RAB10 Homo sapiens P61026
Anti Tag CoIP
29125462
种属内
RILPL2 Q969X0 RAB8A Homo sapiens P61006
Pull Down
32017888
种属内
RILPL2 Q969X0 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Y2H
21911577
种属内
RILPL2 Q969X0 Q99IB8-PRO_0000045596 Hepatitis C virus Q99IB8-PRO_0000045596
Y2H
24136289
种属内
RILPL2 Q969X0 Q99IB8-PRO_0000045592 Hepatitis C virus Q99IB8-PRO_0000045592
Y2H
24136289
种属内
RILPL2 Q969X0 P29991-PRO_0000037946 Dengue virus type 2 P29991-PRO_0000037946
Split-Luc
21911577
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hepatitis C Virus

Hepatitis C Virus, Susceptibility To

Hepatitis C Virus Infection, Response To Therapy Of

Hcv

Hcv, Susceptibility To

Hepatitis C Virus, Resistance To

Hepatitis C Virus, Response To Therapy Of

Resistance To Hepatitis C Virus

Griscelli Syndrome, Type 1

Griscelli Syndrome Type 1

GS1

Griscelli Syndrome With Neurologic Impairment

Partial Albinism And Primary Neurologic Disease Without Hemophagocytic Syndrome

Griscelli Syndrome, Cutaneous And Neurologic Type

Griscelli-Prunieras Syndrome Type 1

Hypopigmentation-Neurologic Impairment Syndrome

Griscelli Syndrome With Neurological Impairment

Griscelli Syndrome, Cutaneous And Neurological Type

Pigmentary Dilution Of The Skin And Hair, The Presence Of Large Clumps Of Pigment In Hair Shafts

Griscelli Syndrome 1

Griscelli Syndrome With Primary Neurologic Impairment

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus RILPL2 VGNC VGNC:33968
Felis catus RILPL2 VGNC VGNC:64629
Mus musculus RILPL2 MGD MGI:1933112
Macaca mulatta RILPL2 VGNC VGNC:76857
Canis familiaris RILPL2 VGNC VGNC:45578
Rattus norvegicus RILPL2 RGD RGD:1303140