2. Gene
  3. MMP24 - matrix metallopeptidase 24 Gene

MMP24 - matrix metallopeptidase 24 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：基质金属肽酶 24

种属: Homo sapiens

同用名: MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5

基因 ID: 10893 | 基因类型: protein coding

关于 MMP24

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:35,226,690-35,276,998 (from NCBI)

This gene has 1 transcript (splice variant), 198 orthologues and 23 paralogues. Broad expression in kidney (RPKM 9.9), brain (RPKM 8.1) and 25 other tissues.

功能概要

该基因编码基质金属蛋白酶 (MMP) 肽酶 M10 家族的成员。该家族中的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。编码的前原蛋白经过蛋白水解处理以产生成熟的蛋白酶。与大多数分泌的 MMP 不同，这种蛋白酶是膜型 MMP (MT-MMP) 亚家族的成员，包含跨膜结构域并在细胞表面表达。这种蛋白酶的底物包括蛋白质钙粘蛋白 2 和基质金属肽酶 2 (也称为 72 kDa IV 型胶原酶) 。该基因以前被称为 MMP25，但已更名为基质金属肽酶 24 (MMP24) 。[RefSeq 提供，2019 年 10 月]

This gene encodes a member of the peptidase M10 family of Matrix Metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature Protease. Unlike most MMPs, which are secreted, this Protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this Protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]

MMP24 基因产物(1)

mRNA Protein Name
NM_006690.4 NP_006681.1 matrix metalloproteinase-24 preproprotein

MMP24 蛋白结构

PG_binding_1

PG_binding_1: Putative peptidoglycan binding domain (80 - 134)

Peptidase_M10

Peptidase_M10: Matrixin (162 - 327)

Hemopexin

Hemopexin: Hemopexin (388 - 426)

Hemopexin

Hemopexin: Hemopexin (429 - 467)

Hemopexin

Hemopexin: Hemopexin (476 - 522)

Hemopexin

Hemopexin: Hemopexin (526 - 569)

DUF3377

DUF3377: Domain of unknown function (DUF3377) (573 - 645)

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  • 645 a.a.
蛋白主名 其他名称

matrix metalloproteinase-24

matrix metallopeptidase 24 (membrane-inserted)

关联疾病

疾病名称 别名
Acromesomelic Dysplasia 2c

Acromesomelic Dysplasia, Hunter-Thompson Type

Acromesomelic Dysplasia 2c, Hunter-Thompson Type

AMD2C

Acromesomelic Dwarfism

Amdh Acromesomelic Dwarfism

Acromesomelic Dysplasia-2c

Acromesomelic Dysplasia Hunter Thompson Type

Acromesomelic Chondrodysplasia, Hunter-Thompson Type

Amdh

Dysplasia, Acromesomelic, Type 2c, Hunter-Thompson

Acromesomelic Dysplasia Hunter-Thompson Type
Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD

Charcot-Marie-Tooth Neuropathy, Type 2dd

Charcot-Marie-Tooth Disease Type 2dd

Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2

Atp1a1-Related Cmt2

Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd

Charcot-Marie-Tooth Disease 2dd
Winchester Syndrome

WNCHRS

Winchester Disease

Winchester-Grossman Syndrome
Asymptomatic Dengue
Suppurative Periapical Periodontitis

Periapical Abscess

Apical Abscess

Suppurative Apical Periodontitis

Dentoalveolar Abscess

Dental Abscess With Sinus

Dentoalveolar Abscess With Sinus

Dental Sinus

Periapical Abscess Fistula

Apical Tooth Abscess

Apex Abscess

Dental Abscess Nos

Infection Of Tooth Nos

Abscess Of Tooth

Dental Infection Nos
Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 1

Cadasil

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

Casil

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy

Familial Vascular Leukoencephalopathy

CADASIL1

Cadasil 1

Hereditary Multi-Infarct Dementia

Cadasil Syndrome

Dementia, Hereditary Multiinfarct Type

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy 1

Autosomal Dominant Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy Type 1

Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts Leukoencephalopathy

Dementia, Hereditary Multi-Infarct Type

Hereditary Dementia, Multi-Infarct Type

Cerebral Autosomal Dominant Arteriopathy-Subcortical Infarcts-Leukoencephalopathy

Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, 1

Cerebral Arteriopathy With Subcortical Infarcts And Leukoencephalopathy, Autosomal Dominant

Dementia Hereditary Multiinfarct Type

Dementia Hereditary Multi-Infarct Type

Arteriopathy, Cerebral, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08543 MMP24 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MMP24 RGD RGD:620202
Canis familiaris MMP24 VGNC VGNC:43283
Mus musculus MMP24 MGD MGI:1341867
Bos taurus MMP24 VGNC VGNC:31526
Felis catus MMP24 VGNC VGNC:68289
Macaca mulatta MMP24 VGNC VGNC:74899
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