STARD3 - StAR related lipid transfer domain containing 3 Gene

中文名称：含 StAR 相关脂质转移结构域 3

种属: Homo sapiens

同用名: CAB1; es64; MLN64

基因 ID: 10948 | 基因类型: protein coding

关于 STARD3

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,637,144-39,664,201 (from NCBI)

This gene has 29 transcripts (splice variants), 212 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 14.1), spleen (RPKM 13.2) and 25 other tissues.

功能概要

该基因编码脂质运输蛋白亚家族的成员，其特征在于 C 端类固醇生成急性调节结构域和 N 端转移性淋巴结 64 结构域。编码的蛋白质定位于晚期核内体的膜，并可能参与输出胆固醇。可变剪接导致多个转录变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late endosomes and may be involved in exporting Cholesterol. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

STARD3 基因产物(3)

mRNA	Protein	Name
NM_001165937.2	NP_001159409.1	stAR-related lipid transfer protein 3 isoform 2
NM_001165938.2	NP_001159410.1	stAR-related lipid transfer protein 3 isoform 3
NM_006804.4	NP_006795.3	stAR-related lipid transfer protein 3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cholesterol binding	IDA IDA: 通过直接分析推断	12011453	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15718238	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	15718238	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cholesterol transport	IDA IDA: 通过直接分析推断	28377464	GOA
involved in vesicle tethering to endoplasmic reticulum	IDA IDA: 通过直接分析推断	24105263	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
colocalizes with endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	24105263	GOA
located in endoplasmic reticulum-endosome membrane contact site	IDA IDA: 通过直接分析推断	24105263	GOA
located in endosome	IDA IDA: 通过直接分析推断	29858488	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	24105263	GOA
located in organelle membrane contact site	IDA IDA: 通过直接分析推断	24105263	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STARD3 蛋白结构

MENTAL

START

0
100
200
300
400
445 a.a.

蛋白主名

其他名称

stAR-related lipid transfer protein 3

MLN 64

STARD3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	STARD3	Q14849	RNF170	Homo sapiens	Q96K19-5	Y2H Prey Pooling	32296183
种属内	STARD3	Q14849	RNF170	Homo sapiens	Q96K19-5	Validated Y2H	32296183
种属内	STARD3	Q14849	RNF170	Homo sapiens	Q96K19-5	Y2H Array	32296183
种属内	STARD3	Q14849	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
种属内	STARD3	Q14849	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
种属内	STARD3	Q14849	MOSPD2	Homo sapiens	Q8NHP6	Pull Down	29858488
种属内	STARD3	Q14849	MOSPD2	Homo sapiens	Q8NHP6	Anti Tag CoIP	29858488
种属内	STARD3	Q14849	MOSPD2	Homo sapiens	Q8NHP6	Confocal	29858488
种属内	STARD3	Q14849	GOPC	Homo sapiens	Q9HD26	Y2H Array	25416956
种属内	STARD3	Q14849	CBARP	Homo sapiens	Q8N350	Anti Tag CoIP	33961781
种属内	STARD3	Q14849	CBARP	Homo sapiens	Q8N350	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

C Syndrome

Opitz Trigonocephaly Syndrome	Trigonocephaly
Trigonocephaly Syndrome	Trigonocephaly C Syndrome
Opitz C Trigonocephaly	Opitz Trigonocephaly C Syndrome
Otcs	CSYN

Lipoid Congenital Adrenal Hyperplasia

Congenital Adrenal Hyperplasia	Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency
Congenital Lipoid Adrenal Hyperplasia	Lipoid Cah
Lipoid Adrenal Hyperplasia	Adrenal Hyperplasia 1
Cah	Clah
LCAH	Adrenal Hyperplasia I
Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism	Congenital Adrenal Hyperplasia Lipoid
Adrenal Hyperplasia, Congenital	Congenital Adrenal Hyperplasia, Lipoid
AH1	Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism
Adrenal Hyperplasia Congenital	Hyperplasia, Adrenal, Lipoid, Congenital
Congenital Adrenogenital Disorders Associated With Enzyme Deficiency	Congenital Adrenal Cortical Hyperplasia
Congenital Adrenal Gland Hyperplasia	Congenital Adrenogenital Syndrome
Congenital Hyperadrenocorticism	Congenital Adrenogenitalism
Congenital Female Adrenal Pseudohermaphroditism

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13878	STARD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS13879	STARD3NL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	STARD3	VGNC	VGNC:65753
Canis familiaris	STARD3	VGNC	VGNC:46882
Mus musculus	STARD3	MGD	MGI:1929618
Bos taurus	STARD3	VGNC	VGNC:35363
Rattus norvegicus	STARD3	RGD	RGD:1549768
Macaca mulatta	STARD3	VGNC	VGNC:77941

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

STARD3 - StAR related lipid transfer domain containing 3 Gene

关于 STARD3

功能概要

STARD3 基因产物(3)

STARD3 蛋白结构

STARD3 蛋白互作信息

关联疾病

直系同源

热门区域

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STARD3 - StAR related lipid transfer domain containing 3 Gene

关于 STARD3

功能概要

STARD3 基因产物(3)

STARD3 蛋白结构

STARD3 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z