1. Gene
  2. KIF2C - kinesin family member 2C Gene

KIF2C - kinesin family member 2C Gene

中文名称:驱动蛋白家族成员 2C

种属: Homo sapiens

同用名: MCAK; CT139; KNSL6

基因 ID: 11004 | 基因类型: protein coding

关于 KIF2C

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,739,837-44,767,767 (from NCBI)

This gene has 8 transcripts (splice variants), 127 orthologues and 41 paralogues. Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues.

功能概要

该基因编码一种驱动蛋白样蛋白,可作为微管依赖性分子马达发挥作用。编码的蛋白质可以解聚加端的微管,从而促进有丝分裂染色体分离。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 7 月]

This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

KIF2C 基因产物(4)

mRNA Protein Name
NM_001297655.2 NP_001284584.1 kinesin-like protein KIF2C isoform 2
NM_001297656.2 NP_001284585.1 kinesin-like protein KIF2C isoform 3
NM_001297657.2 NP_001284586.1 kinesin-like protein KIF2C isoform 4
NM_006845.4 NP_006836.2 kinesin-like protein KIF2C isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables microtubule plus-end binding IDA
IDA: 通过直接分析推断
19632184 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11092768 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in attachment of mitotic spindle microtubules to kinetochore IMP
IMP: 通过突变表型推断
23891108 GOA
involved in establishment or maintenance of microtubule cytoskeleton polarity IMP
IMP: 通过突变表型推断
14718566 GOA
involved in metaphase chromosome alignment IMP
IMP: 通过突变表型推断
23891108 GOA
involved in microtubule depolymerization IDA
IDA: 通过直接分析推断
21820309 GOA
involved in microtubule depolymerization IMP
IMP: 通过突变表型推断
19060894 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: 通过突变表型推断
15843429 GOA
involved in regulation of chromosome segregation IMP
IMP: 通过突变表型推断
19060894 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
14960279 GOA
colocalizes with kinetochore IDA
IDA: 通过直接分析推断
14960279 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
23891108 GOA
located in microtubule plus-end IDA
IDA: 通过直接分析推断
21820309 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

KIF2C 蛋白结构

Kinesin

Kinesin: Kinesin motor domain (264 - 587)

  • 0
  • 200
  • 400
  • 600
  • 725 a.a.
蛋白主名 其他名称

kinesin-like protein KIF2C

kinesin-like protein 6

KIF2C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra KIF2C Q99661 MAPRE1 Homo sapiens Q15691
Pull Down
19632184
Intra KIF2C Q99661 MAPRE1 Homo sapiens Q15691
Pull Down
19543227
Intra KIF2C Q99661 MTUS2 Homo sapiens Q5JR59
IF
19543227
Intra KIF2C Q99661 MTUS2 Homo sapiens Q5JR59
Pull Down
19543227
Intra KIF2C Q99661 SGF29 Homo sapiens Q96ES7
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Bos taurus KIF2C VGNC VGNC:30601
Felis catus KIF2C VGNC VGNC:67974
Mus musculus KIF2C MGD MGI:1921054
Macaca mulatta KIF2C VGNC VGNC:74034
Rattus norvegicus KIF2C RGD RGD:620239
Canis familiaris KIF2C VGNC VGNC:42403