2. Gene
  3. Ehmt2 - euchromatic histone lysine N-methyltransferase 2 Gene

Ehmt2 - euchromatic histone lysine N-methyltransferase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：常染色质组蛋白赖氨酸 N-甲基转移酶 2

种属: Mus musculus

同用名: G9a; Bat8; NG36; KMT1C; D17Ertd710e

基因 ID: 110147 | 基因类型: protein coding

关于 Ehmt2

Chromosome 17: 35,117,445-35,133,028 forward strand.GRCm39:CM001010.3

This gene has 14 transcripts (splice variants), 210 orthologues, 20 paralogues and is associated with 22 phenotypes. Ubiquitous expression in ovary adult (RPKM 86.7), testis adult (RPKM 83.8) and 28 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 C2H2 锌指结构域结合活性；组蛋白-赖氨酸 N-甲基转移酶活性；和启动子特异性染色质结合活性。参与DNA甲基化；组蛋白甲基化；和 DNA 复制的调节。作用于几个过程的上游或内部，包括大分子甲基化；自噬体组装的负调控；和对可卡因的反应。位于核内。以多种结构表达，包括消化系统；肢;神经系统;呼吸系统;和感觉器官。该基因的人类直系同源物与特发性肺纤维化有关。与人类 EHMT2（常染色质组蛋白赖氨酸甲基转移酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including C2H2 zinc finger domain binding activity; histone-lysine N-methyltransferase activity; and promoter-specific chromatin binding activity. Involved in DNA methylation; histone methylation; and regulation of DNA replication. Acts upstream of or within several processes, including macromolecule methylation; negative regulation of autophagosome assembly; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ehmt2 基因产物(7)

mRNA Protein Name
NM_001286573.2 NP_001273502.1 histone-lysine N-methyltransferase EHMT2 isoform c
NM_147151.3 NP_671493.1 histone-lysine N-methyltransferase EHMT2 isoform b
NM_001403867.1 NP_001390796.1 histone-lysine N-methyltransferase EHMT2 isoform e
NM_145830.3 NP_665829.1 histone-lysine N-methyltransferase EHMT2 isoform a
NM_001403870.1 NP_001390799.1 histone-lysine N-methyltransferase EHMT2 isoform g
NM_001286575.2 NP_001273504.1 histone-lysine N-methyltransferase EHMT2 isoform d
NM_001403869.1 NP_001390798.1 histone-lysine N-methyltransferase EHMT2 isoform f
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables C2H2 zinc finger domain binding IPI
IPI: 通过物理相互作用推断
16702210 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21402781 MGI
enables histone H3K27 methyltransferase activity IDA
IDA: 通过直接分析推断
15774718 MGI
enables histone H3K27 methyltransferase activity IMP
IMP: 通过突变表型推断
17212651 MGI
enables histone H3K56 methyltransferase activity IMP
IMP: 通过突变表型推断
22387026 MGI
enables histone H3K9 methyltransferase activity EXP
EXP: 通过实验结果推断
17707230 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: 通过直接分析推断
15774718 MGI
enables histone H3K9 methyltransferase activity IMP
IMP: 通过突变表型推断
15788566 MGI
enables promoter-specific chromatin binding IDA
IDA: 通过直接分析推断
22770845 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15774718 MGI
enables protein-lysine N-methyltransferase activity IDA
IDA: 通过直接分析推断
19144645 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA methylation-dependent heterochromatin formation IDA
IDA: 通过直接分析推断
18818694 MGI
acts upstream of or within behavioral response to cocaine IMP
IMP: 通过突变表型推断
24584053 MGI
acts upstream of or within cellular response to cocaine IDA
IDA: 通过直接分析推断
24584053 MGI
acts upstream of or within fertilization IMP
IMP: 通过突变表型推断
17599069 MGI
acts upstream of or within negative regulation of autophagosome assembly IMP
IMP: 通过突变表型推断
23918802 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IMP
IMP: 通过突变表型推断
17212651 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17392792 MGI
acts upstream of or within neuron fate specification IMP
IMP: 通过突变表型推断
24584053 MGI
acts upstream of or within oocyte development IMP
IMP: 通过突变表型推断
17599069 MGI
acts upstream of or within organ growth IMP
IMP: 通过突变表型推断
17599069 MGI
acts upstream of or within phenotypic switching IMP
IMP: 通过突变表型推断
24584053 MGI
acts upstream of or within protein methylation IMP
IMP: 通过突变表型推断
17599069 MGI
involved in regulation of DNA replication IMP
IMP: 通过突变表型推断
22387026 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
17599069 MGI
acts upstream of or within spermatid development IMP
IMP: 通过突变表型推断
17599069 MGI
acts upstream of or within synaptonemal complex assembly IMP
IMP: 通过突变表型推断
17599069 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
NOT located in nucleolus IDA
IDA: 通过直接分析推断
16702210 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15493016 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Ehmt2 蛋白结构

PHA03247

PHA03247: cl33720 (4 - 257)

EHMT_ZBD

EHMT_ZBD: cd20905 (472 - 601)

ANKYR

ANKYR: COG0666 (681 - 873)

ANK

ANK: sd00045 (738 - 767)

Ank_2

Ank_2: pfam12796 (774 - 867)

ANK

ANK: sd00045 (802 - 834)

ANK

ANK: sd00045 (837 - 867)

Ank_2

Ank_2: pfam12796 (841 - 933)

ANK

ANK: sd00045 (869 - 900)

ANK

ANK: sd00045 (902 - 933)

SET_EHMT2

SET_EHMT2: cd10533 (1000 - 1238)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1263 a.a.
蛋白主名 其他名称

histone-lysine N-methyltransferase EHMT2

H3-K9-HMTase 3

HLA-B associated transcript 8

histone H3-K9 methyltransferase 3

histone-lysine N-methyltransferase, H3 lysine-9 specific 3

protein G9a

Ehmt2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Ehmt2 Q9Z148 Hoxa9 Mus musculus P09631
Anti Tag CoIP
24532712
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-16705 BRD4770 Inhibitor 99.69% 否
HY-111904 EHMT2-IN-2 Inhibitor ≥99.0% 否
HY-15647 BRD9539 Inhibitor 99.74% 否
HY-111778 EHMT2-IN-1 Inhibitor 99.85% 否
HY-161759 MS152 Inhibitor 99.36% 否
HY-133031 CSV0C018875 Inhibitor / 否
HY-133031A CSV0C018875 hydrochloride Inhibitor / 否
HY-44062 G9a-IN-1 Inhibitor 98.12% 否
HY-RS04230 EHMT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04231 Ehmt2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04232 Ehmt2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ehmt2 NCBI NCBI:10919
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