2. Gene
  3. PIM2 - Pim-2 proto-oncogene, serine/threonine kinase Gene

PIM2 - Pim-2 proto-oncogene, serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Pim-2 原癌基因，丝氨酸/苏氨酸激酶

种属: Homo sapiens

基因 ID: 11040 | 基因类型: protein coding

关于 PIM2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,913,182-48,919,024 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 2 paralogues. Broad expression in lymph node (RPKM 45.7), appendix (RPKM 40.1) and 20 other tissues.

功能概要

该基因编码的原癌基因充当丝氨酸/苏氨酸蛋白激酶。研究确定编码的蛋白质具有防止细胞凋亡和促进细胞存活的功能。[RefSeq 提供，2009 年 11 月]

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent Apoptosis and to promote cell survival.[provided by RefSeq, Nov 2009]

PIM2 基因产物(2)

mRNA Protein Name
NM_006875.4 NP_006866.2 serine/threonine-protein kinase pim-2
XM_047441792.1 XP_047297748.1 serine/threonine-protein kinase pim-2 isoform X1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16713569 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18593906 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
20307683 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
18675992 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
20307683 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
18593906 GOA
involved in protein stabilization IMP
IMP: 通过突变表型推断
20307683 GOA
involved in response to virus IEP
IEP: 通过表达模式推断
16548883 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIM2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (32 - 286)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase pim-2

pim-2 oncogene

pim-2h

proto-oncogene Pim-2 (serine threonine kinase)

PIM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PIM2 Q9P1W9 ZNF821 Homo sapiens O75541
Y2H Prey Pooling
25416956
种属内
PIM2 Q9P1W9 ATXN1 Homo sapiens P54253
Y2H Array
16713569
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Croup

Acute Obstructive Laryngitis

Laryngotracheobronchitis

Acute Laryngotracheobronchitis

Croup Syndrome

Acute Laryngitis With Obstruction

Obstructive Laryngitis

Obstructive Laryngitis Nos

Obstructive Laryngotracheitis Nos
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-101870B Uzansertib phosphate Inhibitor 99.39% Phase 2
HY-101870 Uzansertib Inhibitor / Phase 2
HY-15604 AZD1208 Inhibitor 99.71% Phase 1
HY-19322B PIM-447 dihydrochloride Inhibitor 99.94% Phase 1
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15698A CRT0066101 dihydrochloride Inhibitor 99.92% 否
HY-16576A SMI-4a Inhibitor 99.63% 否
HY-N4149 Quercetagetin Inhibitor 99.94% 否
HY-16976 GDC-0339 Inhibitor 99.87% 否
HY-101947 SMI-16a Inhibitor ≥98.0% 否
HY-120758 SEL24-B489 Inhibitor 99.02% 否
HY-15698 CRT0066101 Inhibitor 99.66% 否
HY-111552 PIM1-IN-1 Inhibitor 99.83% 否
HY-122665 HTH-01-091 Inhibitor 98.64% 否
HY-164460 AZD1897 Inhibitor 99.69% 否
HY-163119 Pim-1 kinase inhibitor 9 Inhibitor / 否
HY-163442A PIM3-IN-1 hydrochloride Inhibitor / 否
HY-15698B CRT0066101 trihydrochloride Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-160006 PIM-IN-2 / 否
HY-123983 HS56 Inhibitor / 否
HY-157404 Pim-1/2 kinase inhibitor 2 Inhibitor / 否
HY-101783 GNE-955 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PIM2 MGD MGI:97587
Canis familiaris PIM2 VGNC VGNC:44565
Felis catus PIM2 VGNC VGNC:68861
Bos taurus PIM2 VGNC VGNC:32900
Rattus norvegicus PIM2 RGD RGD:1560759
Others PIM2 NCBI
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