2. Gene
  3. TMEM115 - transmembrane protein 115 Gene

TMEM115 - transmembrane protein 115 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：跨膜蛋白 115

种属: Homo sapiens

同用名: PL6

基因 ID: 11070 | 基因类型: protein coding

关于 TMEM115

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:50,354,750-50,359,521 (from NCBI)

This gene has 1 transcript (splice variant) and 203 orthologues. Ubiquitous expression in placenta (RPKM 15.3), kidney (RPKM 14.6) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性。参与逆行囊泡介导的转运，高尔基体到内质网。位于高尔基池膜和细胞核内。与高尔基体运输复合体共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in Golgi cisterna membrane and nucleus. Colocalizes with Golgi transport complex. [provided by Alliance of Genome Resources, Apr 2022]

TMEM115 基因产物(1)

mRNA Protein Name
NM_007024.5 NP_008955.1 transmembrane protein 115
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
24806965 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24806965 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
IMP: 通过突变表型推断
24806965 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
17973242 GOA
located in Golgi cisterna membrane IDA
IDA: 通过直接分析推断
24806965 GOA
part of Golgi transport complex IDA
IDA: 通过直接分析推断
24806965 GOA
located in nucleus IDA
IDA: 通过直接分析推断
17973242 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMEM115 蛋白结构

DUF1751

DUF1751: Eukaryotic integral membrane protein (DUF1751) (49 - 151)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
蛋白主名 其他名称

transmembrane protein 115

PP6

TMEM115 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TMEM115 Q12893 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
Intra TMEM115 Q12893 HTATIP2 Homo sapiens Q9BUP3-3
Validated Y2H
32296183
Intra TMEM115 Q12893 TLCD4 Homo sapiens Q96MV1
Y2H Array
32296183
Intra TMEM115 Q12893 TLCD4 Homo sapiens Q96MV1
Y2H Prey Pooling
32296183
Intra TMEM115 Q12893 TLCD4 Homo sapiens Q96MV1
Validated Y2H
32296183
Intra TMEM115 Q12893 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra TMEM115 Q12893 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra TMEM115 Q12893 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra TMEM115 Q12893 ASPG Homo sapiens Q86U10
Y2H Prey Pooling
32296183
Intra TMEM115 Q12893 ASPG Homo sapiens Q86U10
Validated Y2H
32296183
Intra TMEM115 Q12893 ASPG Homo sapiens Q86U10
Y2H Array
32296183
Intra TMEM115 Q12893 LAMP2 Homo sapiens P13473-2
Y2H Pooling
32814053
Intra TMEM115 Q12893 LAMP2 Homo sapiens P13473-2
Validated Y2H
32814053
Intra TMEM115 Q12893 LAMP2 Homo sapiens P13473-2
Y2H Array
32814053
Intra TMEM115 Q12893 SH3GLB1 Homo sapiens Q9Y371
Validated Y2H
32814053
Intra TMEM115 Q12893 SH3GLB1 Homo sapiens Q9Y371
Y2H Array
32814053
Intra TMEM115 Q12893 SH3GLB1 Homo sapiens Q9Y371
Y2H Pooling
32814053
Intra TMEM115 Q12893 MANBAL Homo sapiens Q9NQG1
Y2H Array
32296183
Intra TMEM115 Q12893 MANBAL Homo sapiens Q9NQG1
Y2H Prey Pooling
32296183
Intra TMEM115 Q12893 MANBAL Homo sapiens Q9NQG1
Validated Y2H
32296183
Intra TMEM115 Q12893 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra TMEM115 Q12893 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra TMEM115 Q12893 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra TMEM115 Q12893 RABAC1 Homo sapiens Q9UI14
Validated Y2H
32296183
Intra TMEM115 Q12893 SYNE4 Homo sapiens Q8N205
Validated Y2H
25416956
Intra TMEM115 Q12893 SYNE4 Homo sapiens Q8N205
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2

SRTD2

Atd2

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 2
Louse-Borne Relapsing Fever

Relapsing Fever, Louse-Borne

Relapsing Fever Due To Borrelia Recurrentis
Tick-Borne Relapsing Fever

Relapsing Fever, Tick-Borne

Relapsing Fever Due To Any Borrelia Species Other Than Borrelia Recurrentis

African Tick-Borne Fever
Uterus Carcinoma In Situ
Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix

Carcinoma In Situ Of Uterine Cervix

Cervical Intraepithelial Neoplasia

Carcinoma Of Cervix Stage 0

Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

Cervix Ca In Situ

Cin Iii

Cin Iii - Carcinoma In Situ Of Cervix

Cin Iii - Severe Dyskaryosis

Severe Dysplasia Of Cervix

Severe Dysplasia Of The Cervix Uteri

Squamous Intraepithelial Neoplasia, Grade Iii

Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Gaucher Disease, Type Iiic

Gaucher Disease-Ophthalmoplegia-Cardiovascular Calcification Syndrome

Gaucher-Like Disease

GD3C

Gaucher'S Disease Type Iiic

Cardiovascular Gaucher Disease

Gaucher Disease Type 3c

Gaucher Disease 3c

Pseudo-Gaucher Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14652 TMEM115 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TMEM115 VGNC VGNC:47452
Felis catus TMEM115 VGNC VGNC:66261
Bos taurus TMEM115 VGNC VGNC:35952
Rattus norvegicus TMEM115 RGD RGD:1310540
Macaca mulatta TMEM115 VGNC VGNC:110327
Mus musculus TMEM115 MGD MGI:1930765
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z