TPPP - tubulin polymerization promoting protein Gene

中文名称：微管蛋白聚合促进蛋白

种属: Homo sapiens

同用名: p24; p25; TPPP1; TPPP/p25; p25alpha

基因 ID: 11076 | 基因类型: protein coding

关于 TPPP

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:659,862-700,727 (from NCBI)

This gene has 1 transcript (splice variant), 192 orthologues and 2 paralogues. Biased expression in brain (RPKM 45.7), lung (RPKM 7.7) and 9 other tissues.

功能概要

启用多项功能，包括 GTPase 活动；镁离子结合活性；和蛋白质同二聚化活性。参与多个过程，包括微管细胞骨架组织；微管蛋白去乙酰化的负调节；和蛋白质聚合的正调节。位于几种细胞成分中，包括线粒体；有丝分裂纺锤体;和细胞质的核周区。与微管和微管束共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including GTPase activity; magnesium ion binding activity; and protein homodimerization activity. Involved in several processes, including microtubule Cytoskeleton organization; negative regulation of tubulin deacetylation; and positive regulation of protein polymerization. Located in several cellular components, including mitochondrion; mitotic spindle; and perinuclear region of cytoplasm. Colocalizes with microtubule and microtubule bundle. [provided by Alliance of Genome Resources, Apr 2022]

TPPP 基因产物(1)

mRNA	Protein	Name
NM_007030.3	NP_008961.1	tubulin polymerization-promoting protein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activity	IDA IDA: 通过直接分析推断	21316364	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	21316364	GOA
enables microtubule nucleator activity	IDA IDA: 通过直接分析推断	31522887	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15590652	GOA
enables protein dimerization activity	IDA IDA: 通过直接分析推断	22484033	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	26289831	GOA
enables tubulin binding	IDA IDA: 通过直接分析推断	17105200	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in astral microtubule organization	IDA IDA: 通过直接分析推断	22328514	GOA
involved in microtubule bundle formation	IDA IDA: 通过直接分析推断	17105200	GOA
involved in microtubule nucleation by microtubule organizing center	IDA IDA: 通过直接分析推断	31522887	GOA
involved in microtubule polymerization	IDA IDA: 通过直接分析推断	18028908	GOA
involved in negative regulation of tubulin deacetylation	IDA IDA: 通过直接分析推断	20308065	GOA
involved in positive regulation of protein polymerization	IDA IDA: 通过直接分析推断	15590652	GOA
involved in regulation of microtubule cytoskeleton organization	IDA IDA: 通过直接分析推断	23093407	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in Golgi apparatus	IDA IDA: 通过直接分析推断	31522887	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18028908	GOA
colocalizes with microtubule	IDA IDA: 通过直接分析推断	18028908	GOA
colocalizes with microtubule bundle	IDA IDA: 通过直接分析推断	17105200	GOA
located in mitotic spindle	IDA IDA: 通过直接分析推断	22328514	GOA
located in nucleus	IDA IDA: 通过直接分析推断	18028908	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	15590652	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPPP 蛋白结构

p25-alpha

0
100
200
219 a.a.

蛋白主名

其他名称

tubulin polymerization-promoting protein

25 kDa brain-specific protein

TPPP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TPPP	O94811	ZNF114	Homo sapiens	Q8NC26	Validated Y2H	32296183
种属内	TPPP	O94811	H1-1	Homo sapiens	Q02539	Crosslink	30021884
种属内	TPPP	O94811	SNCA	Homo sapiens	P37840	ELISA	27671864
种属内	TPPP	O94811	SNCA	Homo sapiens	P37840	CD	27671864
种属内	TPPP	O94811	SNCA	Homo sapiens	P37840	NMR	27671864
种属内	TPPP	O94811	SNCA	Homo sapiens	P37840	BiFC	27671864

种属间: 跨种属相互作用 种属内: 同种属相互作用

TPPP 抗体

目录号	产品名	应用	反应物种
HY-P82440	TPPP Antibody (YA2185)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 3

MRD3	Autosomal Dominant Non-Syndromic Intellectual Disability 3
Mental Retardation, Autosomal Dominant 3	Autosomal Dominant Intellectual Developmental Disorder 3

Striatonigral Degeneration

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Olivopontocerebellar Atrophy

Thomas Syndrome	Olivopontocerebellar Atrophies
Dejerine-Thomas Syndrome	Thomas' Syndrome
Wadia-Swami Syndrome	Opca
Potter Sequence-Cleft Lip/Palate-Cardiopathy Syndrome	Spinocerebellar Ataxia Type 2

Schizophrenia 13

SCZD13	Schizophrenia Susceptibility Locus, Chromosome 15q13-Q14-Related
Schizophrenia, Susceptibility To, 13

Multiple System Atrophy 1

Multiple System Atrophy	Shy-Drager Syndrome
Msa	MSA1
Multiple System Atrophy 1, Susceptibility To	Sporadic Olivopontocerebellar Atrophy
Multisystem Atrophy	Msa1, Susceptibility To
Multiple System Atrophy, Susceptibility To	Opca
Progressive Autonomic Failure With Multiple System Atrophy	Sds

Dementia, Lewy Body

Lewy Body Dementia	Lewy Body Disease
Diffuse Lewy Body Disease	Dementia With Lewy Bodies
DLB	Autosomal Dominant Diffuse Lewy Body Disease
Cortical Lewy Body Disease	Dementia, Lewy Body, Susceptibility To
Lewy Body Dementia, Susceptibility To	Senile Dementia Of The Lewy Body Type
Dementia Of The Lewy Body Type	Lbd
Diffuse Lewy Body Disease With Gaze Palsy	Dysphasic Dementia Hereditary
Lewy Body Type Senile Dementia	Lewy Body Variant Of Alzheimer Disease
Lewy Bodies	Lewy Body
Dlbd - [Diffuse Lewy Body Disease]	Clbd - [Cortical Lewy Body Disease]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14944	TPPP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS14945	TPPP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	TPPP	VGNC	VGNC:102351
Bos taurus	TPPP	VGNC	VGNC:36258
Mus musculus	TPPP	MGD	MGI:1920198
Canis familiaris	TPPP	VGNC	VGNC:47749
Rattus norvegicus	TPPP	RGD	RGD:1310121
Others	TPPP	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TPPP - tubulin polymerization promoting protein Gene

关于 TPPP

功能概要

TPPP 基因产物(1)

TPPP 蛋白结构

TPPP 蛋白互作信息

TPPP 抗体

关联疾病

直系同源

热门区域

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TPPP - tubulin polymerization promoting protein Gene

关于 TPPP

功能概要

TPPP 基因产物(1)

TPPP 蛋白结构

TPPP 蛋白互作信息

TPPP 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z