1. Gene
  2. PRDM4 - PR/SET domain 4 Gene

PRDM4 - PR/SET domain 4 Gene

中文名称:PR/SET 域 4

种属: Homo sapiens

同用名: PFM1

基因 ID: 11108 | 基因类型: protein coding

关于 PRDM4

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:107,732,871-107,761,137 (from NCBI)

This gene has 6 transcripts (splice variants), 217 orthologues and 51 paralogues. Ubiquitous expression in kidney (RPKM 10.4), esophagus (RPKM 8.7) and 25 other tissues.

功能概要

该基因编码的蛋白质是 PR 结构域蛋白质家族的转录因子。它包含一个 PR 结构域和多个锌指基序。已知 PR 结构域家族的转录因子参与细胞分化和肿瘤发生。在用神经生长因子、β 多肽 (NGF) 处理的 PC12 细胞中观察到该基因的表达水平升高。该基因位于被认为含有抑癌基因的染色体区域。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

PRDM4 基因产物(1)

mRNA Protein Name
NM_012406.4 NP_036538.3 PR domain zinc finger protein 4
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PRDM4 蛋白结构

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (632 - 656)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (660 - 683)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (688 - 712)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (730 - 752)

  • 0
  • 200
  • 400
  • 600
  • 801 a.a.
蛋白主名 其他名称

PR domain zinc finger protein 4

PR domain 4

PRDM4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra PRDM4 Q9UKN5 CTNNBL1 Homo sapiens Q8WYA6
Y2H Prey Pooling
25416956
Intra PRDM4 Q9UKN5 MSRB3 Homo sapiens Q8IXL7
Validated Y2H
25416956
Intra PRDM4 Q9UKN5 MSRB3 Homo sapiens Q8IXL7
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Porokeratosis

Disseminated Superficial Actinic Porokeratosis

Dsap

Porokeratosis Of Mibelli

Porokeratosis, Disseminated Superficial Actinic

Porokeratosis, Disseminated Superficial Actinic, 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRDM4 MGD MGI:1920093
Canis familiaris PRDM4 VGNC VGNC:44949
Bos taurus PRDM4 VGNC VGNC:33296
Felis catus PRDM4 VGNC VGNC:69034
Macaca mulatta PRDM4 VGNC VGNC:76393
Rattus norvegicus PRDM4 RGD RGD:619929