CD160 - CD160 molecule Gene

中文名称：CD160 分子

种属: Homo sapiens

同用名: NK1; BY55; NK28

关于 CD160

功能概要

CD160 是一种 27 kDa 的糖蛋白，最初是用单克隆抗体 BY55 鉴定的。其表达与外周血 NK 细胞和具有溶细胞效应活性的 CD8 T 淋巴细胞密切相关。 CD160 的 cDNA 序列预测富含半胱氨酸的糖基磷脂酰肌醇锚定蛋白，由 181 个氨基酸组成，具有与 KIR2DL4 分子弱同源的单个 Ig 样结构域。 CD160 在细胞表面表达为紧密二硫键连接的多聚体。 RNA 印迹分析显示 1.5 和 1.6 kb 的 CD160 mRNA，其表达高度限于循环 NK 和 T 细胞、脾脏和小肠。在 NK 细胞内，CD160 由 CD56dimCD16+ 细胞表达，而在循环 T 细胞中，其表达主要限于携带 TCRgd 的细胞和 TCRab+CD8brightCD95+CD56+CD28-CD27 细胞。在组织中，CD160 在所有肠上皮内淋巴细胞上表达。 CD160 显示出与经典和非经典 MHC I 类分子结合的广泛特异性。[RefSeq 提供，2008 年 7 月]

CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 Amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules. [provided by RefSeq, Jul 2008]