CORO1A - coronin 1A Gene

中文名称：冠宁 1A

种属: Homo sapiens

同用名: p57; IMD8; TACO; CLABP; HCORO1; CLIPINA

基因 ID: 11151 | 基因类型: protein coding

关于 CORO1A

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,183,602-30,189,076 (from NCBI)

This gene has 18 transcripts (splice variants), 186 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues.

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域，通常由 gly-his 和 trp-asp (GH-WD) 括起来，这可能有助于异源三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程，包括细胞周期进程、信号转导、细胞凋亡和基因调控。可变剪接导致多个转录本变体。已在 16 号染色体上定义了一个相关的假基因。[RefSeq 提供，2010 年 9 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

CORO1A 基因产物(2)

mRNA	Protein	Name
NM_001193333.3	NP_001180262.1	coronin-1A
NM_007074.4	NP_009005.1	coronin-1A

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables actin binding	IPI IPI: 通过物理相互作用推断	23100250	GOA
enables actin filament binding	IDA IDA: 通过直接分析推断	7758584	GOA
enables actin filament binding	IMP IMP: 通过突变表型推断	22364218	GOA
enables actin monomer binding	IMP IMP: 通过突变表型推断	23100250	GOA
enables myosin heavy chain binding	IPI IPI: 通过物理相互作用推断	23100250	GOA
enables phosphatidylinositol 3-kinase binding	IDA IDA: 通过直接分析推断	11094157	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9365277	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	15601263	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin cytoskeleton organization	IMP IMP: 通过突变表型推断	17442961	GOA
involved in cell-substrate adhesion	IMP IMP: 通过突变表型推断	17442961	GOA
NOT involved in immunological synapse formation	IMP IMP: 通过突变表型推断	24760828	GOA
involved in natural killer cell degranulation	IMP IMP: 通过突变表型推断	24760828	GOA
involved in negative regulation of actin nucleation	IDA IDA: 通过直接分析推断	17442961	GOA
involved in phagocytosis	IMP IMP: 通过突变表型推断	17442961	GOA
involved in phagolysosome assembly	IMP IMP: 通过突变表型推断	12132654	GOA
involved in positive chemotaxis	IDA IDA: 通过直接分析推断	17442961	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: 通过突变表型推断	24760828	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin filament	IDA IDA: 通过直接分析推断	15800061	GOA
colocalizes with cortical actin cytoskeleton	IDA IDA: 通过直接分析推断	24760828	GOA
located in cortical actin cytoskeleton	IDA IDA: 通过直接分析推断	15800061	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	17341475	GOA
located in immunological synapse	IDA IDA: 通过直接分析推断	24760828	GOA
located in lamellipodium	IDA IDA: 通过直接分析推断	17442961	GOA
NOT located in nucleus	IDA IDA: 通过直接分析推断	17341475	GOA
located in phagocytic cup	IDA IDA: 通过直接分析推断	17442961	GOA
located in phagocytic vesicle	IDA IDA: 通过直接分析推断	17442961	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	17341475	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	11094157	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CORO1A 蛋白结构

DUF1899

WD40

Trimer_CC

0
100
200
300
400
461 a.a.

蛋白主名

其他名称

coronin-1A

clipin-A

CORO1A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CORO1A	P31146	STAT3	Homo sapiens	P40763	Y2H	21988832
种属内	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	32296183
种属内	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	25416956
种属内	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	32296183
种属内	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Array	31515488
种属内	CORO1A	P31146	FSD2	Homo sapiens	A1L4K1	Y2H Prey Pooling	25416956
种属内	CORO1A	P31146	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
种属内	CORO1A	P31146	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
种属内	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Validated Y2H	32296183
种属内	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
种属内	CORO1A	P31146	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
种属内	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Y2H Prey Pooling	32296183
种属内	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Validated Y2H	32296183
种属内	CORO1A	P31146	IFT20	Homo sapiens	Q8IY31-3	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 8

Severe Combined Immunodeficiency Due To Coro1a Deficiency	IMD8
Scid Due To Coro1a Deficiency	Scid Due To Coronin-1a Deficiency
Severe Combined Immunodeficiency Due To Coronin-1a Deficiency	Immunodeficiency, Type 8

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Coronin-1a Deficiency

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Immunodeficiency 19

IMD19	Cd3-Delta Deficiency
Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Cd3delta Deficiency
Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive	Immunodeficiency 19, Severe Combined
Cd3d	Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive
T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid	T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency
Immunodeficiency, Type 19

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Lymphopenia

Lymphocytopenia

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Immunodeficiency 7

Tcr-Alpha-Beta-Positive T-Cell Deficiency	IMD7
T-Cell Receptor-Alpha/Beta Deficiency	Immunodeficiency 7, Tcr-Alpha/Beta Deficient
Tcr-Alpha/Beta Deficiency	Tcr-Alpha-Beta+ T-Cell Deficiency
T-Cell Receptor Alpha/Beta Deficiency

Immunodeficiency 9

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1	Combined Immunodeficiency Due To Orai1 Deficiency
IMD9	Cid Due To Orai1 Deficiency
Severe Combined Immunodeficiency Due To Crac Channel Dysfunction	Immunodeficiency, Type 9

Immunodeficiency 20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity	IMD20
Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity	Cd16 Deficiency
Immunodeficiency, Type 20

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis	Epidermodysplasia Verruciformis, Susceptibility To, 1
Lutz-Lewandowsky Epidermodysplasia Verruciformis	EV1
Lewandowsky-Lutz Syndrome	Ev

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN	X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia	Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia
Cid Due To Magt1 Deficiency	Combined Immunodeficiency Due To Magt1 Deficiency
X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An	X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia

Lymphoproliferative Syndrome 2

Cd27 Deficiency	LPFS2
Combined Immunodeficiency Due To Cd27 Deficiency	Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

T Cell Deficiency

T Cell Immunodeficiency	T Lymphocyte Deficiency
T Lymphocyte Immunodeficiency	T-Lymphocyte Deficiency

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03048	CORO1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CORO1A	VGNC	VGNC:61101
Mus musculus	CORO1A	MGD	MGI:1345961
Macaca mulatta	CORO1A	VGNC	VGNC:71319
Bos taurus	CORO1A	VGNC	VGNC:27620
Canis familiaris	CORO1A	VGNC	VGNC:39527
Rattus norvegicus	CORO1A	RGD	RGD:620009

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CORO1A - coronin 1A Gene

关于 CORO1A

功能概要

CORO1A 基因产物(2)

CORO1A 蛋白结构

CORO1A 蛋白互作信息

关联疾病

直系同源

热门区域

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CORO1A - coronin 1A Gene

关于 CORO1A

功能概要

CORO1A 基因产物(2)

CORO1A 蛋白结构

CORO1A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z