1. Gene
  2. CORO1A - coronin 1A Gene

CORO1A - coronin 1A Gene

中文名称:冠宁 1A

种属: Homo sapiens

同用名: p57; IMD8; TACO; CLABP; HCORO1; CLIPINA

基因 ID: 11151 | 基因类型: protein coding

关于 CORO1A

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,183,602-30,189,076 (from NCBI)

This gene has 18 transcripts (splice variants), 186 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in lymph node (RPKM 216.7), bone marrow (RPKM 179.6) and 10 other tissues.

功能概要

该基因编码 WD 重复蛋白家族的一个成员。 WD 重复是大约 40 个氨基酸的最小保守区域,通常由 gly-his 和 trp-asp (GH-WD) 括起来,这可能有助于异源三聚体或多蛋白复合物的形成。该家族的成员参与多种细胞过程,包括细胞周期进程、信号转导、细胞凋亡和基因调控。可变剪接导致多个转录本变体。已在 16 号染色体上定义了一个相关的假基因。[RefSeq 提供,2010 年 9 月]

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]

CORO1A 基因产物(2)

mRNA Protein Name
NM_001193333.3 NP_001180262.1 coronin-1A
NM_007074.4 NP_009005.1 coronin-1A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IPI
IPI: 通过物理相互作用推断
23100250 GOA
enables actin filament binding IDA
IDA: 通过直接分析推断
7758584 GOA
enables actin filament binding IMP
IMP: 通过突变表型推断
22364218 GOA
enables actin monomer binding IMP
IMP: 通过突变表型推断
23100250 GOA
enables myosin heavy chain binding IPI
IPI: 通过物理相互作用推断
23100250 GOA
enables phosphatidylinositol 3-kinase binding IDA
IDA: 通过直接分析推断
11094157 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9365277 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
15601263 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
17442961 GOA
involved in cell-substrate adhesion IMP
IMP: 通过突变表型推断
17442961 GOA
NOT involved in immunological synapse formation IMP
IMP: 通过突变表型推断
24760828 GOA
involved in natural killer cell degranulation IMP
IMP: 通过突变表型推断
24760828 GOA
involved in negative regulation of actin nucleation IDA
IDA: 通过直接分析推断
17442961 GOA
involved in phagocytosis IMP
IMP: 通过突变表型推断
17442961 GOA
involved in phagolysosome assembly IMP
IMP: 通过突变表型推断
12132654 GOA
involved in positive chemotaxis IDA
IDA: 通过直接分析推断
17442961 GOA
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
24760828 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IDA
IDA: 通过直接分析推断
15800061 GOA
colocalizes with cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
24760828 GOA
located in cortical actin cytoskeleton IDA
IDA: 通过直接分析推断
15800061 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
17341475 GOA
located in immunological synapse IDA
IDA: 通过直接分析推断
24760828 GOA
located in lamellipodium IDA
IDA: 通过直接分析推断
17442961 GOA
NOT located in nucleus IDA
IDA: 通过直接分析推断
17341475 GOA
located in phagocytic cup IDA
IDA: 通过直接分析推断
17442961 GOA
located in phagocytic vesicle IDA
IDA: 通过直接分析推断
17442961 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
17341475 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
11094157 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CORO1A 蛋白结构

DUF1899

DUF1899: Domain of unknown function (DUF1899) (4 - 68)

WD40

WD40: WD domain, G-beta repeat (77 - 110)

WD40

WD40: WD domain, G-beta repeat (122 - 160)

WD40

WD40: WD domain, G-beta repeat (175 - 202)

Trimer_CC

Trimer_CC: Trimerisation motif (259 - 392)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
蛋白主名 其他名称

coronin-1A

clipin-A

CORO1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CORO1A P31146 STAT3 Homo sapiens P40763
Y2H
21988832
Intra CORO1A P31146 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
32296183
Intra CORO1A P31146 FSD2 Homo sapiens A1L4K1
Y2H Array
25416956
Intra CORO1A P31146 FSD2 Homo sapiens A1L4K1
Y2H Array
32296183
Intra CORO1A P31146 FSD2 Homo sapiens A1L4K1
Y2H Array
31515488
Intra CORO1A P31146 FSD2 Homo sapiens A1L4K1
Y2H Prey Pooling
25416956
Intra CORO1A P31146 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra CORO1A P31146 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra CORO1A P31146 MAGEA11 Homo sapiens P43364
Validated Y2H
32296183
Intra CORO1A P31146 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra CORO1A P31146 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra CORO1A P31146 IFT20 Homo sapiens Q8IY31-3
Y2H Prey Pooling
32296183
Intra CORO1A P31146 IFT20 Homo sapiens Q8IY31-3
Validated Y2H
32296183
Intra CORO1A P31146 IFT20 Homo sapiens Q8IY31-3
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Immunodeficiency 8

Severe Combined Immunodeficiency Due To Coro1a Deficiency

IMD8

Scid Due To Coro1a Deficiency

Scid Due To Coronin-1a Deficiency

Severe Combined Immunodeficiency Due To Coronin-1a Deficiency

Immunodeficiency, Type 8

Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]

Coronin-1a Deficiency
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Molluscum Contagiosum

Water Warts

Molluscum Verrucosum

Immunodeficiency 19

IMD19

Cd3-Delta Deficiency

Severe Combined Immunodeficiency, T Cell-Negative, B Cell-Positive, Nk Cell-Positive

Cd3delta Deficiency

Scid, T Cell-Negative, B Cell-Positive, Nk Cell-Positive

Immunodeficiency 19, Severe Combined

Cd3d

Scid T Cell-Negative, B Cell-Positive, Nk Cell-Positive

T Cell-Negative, B Cell-Positive, Nk Cell-Positive Scid

T Cell-Negative, B Cell-Positive, Nk Cell-Positive Severe Combined Immunodeficiency

Immunodeficiency, Type 19

Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40

Lymphopenia

Lymphocytopenia

Chronic Granulomatous Disease

Cgd

Granulomatous Disease, Chronic

Autosomal Recessive Chronic Granulomatous Disease

X-Linked Chronic Granulomatous Disease

Bridges-Good Syndrome

Congenital Dysphagocytosis

Quie Syndrome

Chronic Septic Granulomatosis

Chronic Granulomatous Disorder

Granulomatous Disease Chronic

Granulomatous Disease, Chronic, X-Linked

Immunodeficiency 7

Tcr-Alpha-Beta-Positive T-Cell Deficiency

IMD7

T-Cell Receptor-Alpha/Beta Deficiency

Immunodeficiency 7, Tcr-Alpha/Beta Deficient

Tcr-Alpha/Beta Deficiency

Tcr-Alpha-Beta+ T-Cell Deficiency

T-Cell Receptor Alpha/Beta Deficiency

Immunodeficiency 9

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 1

Combined Immunodeficiency Due To Orai1 Deficiency

IMD9

Cid Due To Orai1 Deficiency

Severe Combined Immunodeficiency Due To Crac Channel Dysfunction

Immunodeficiency, Type 9

Immunodeficiency 20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Natural Killer Cell Cytotoxicity

IMD20

Autosomal Recessive Primary Immunodeficiency With Defective Spontaneous Nk Cell Cytotoxicity

Cd16 Deficiency

Immunodeficiency, Type 20

Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

XMEN

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia

Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection And Neoplasia

Cid Due To Magt1 Deficiency

Combined Immunodeficiency Due To Magt1 Deficiency

X-Linked Immunodeficiency With Magnesium Defect, Epstein-Barr Virus Infection An

X-Linked Magnesium Deficiency With Epstein-Barr Virus Infection And Neoplasia

Lymphoproliferative Syndrome 2

Cd27 Deficiency

LPFS2

Combined Immunodeficiency Due To Cd27 Deficiency

Autosomal Recessive Lymphoproliferative Disease Due To Cd27 Deficiency

Superficial Mycosis

Piedra

Steroid-Modified Tinea Infection

Pityriasis Versicolor

Tinea Versicolor

Infection By Pityrosporum Furfur

T Cell Deficiency

T Cell Immunodeficiency

T Lymphocyte Deficiency

T Lymphocyte Immunodeficiency

T-Lymphocyte Deficiency

Omenn Syndrome

Histiocytic Medullary Reticulosis

Severe Combined Immunodeficiency With Hypereosinophilia

Combined Immunodeficiency With Hypereosinophilia

Reticuloendotheliosis, Familial, With Eosinophilia

Reticuloendotheliosis Familial With Eosinophilia

Familial Reticuloendotheliosis

Omenn'S Syndrome

OS

Malignant Histiocytosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CORO1A VGNC VGNC:61101
Mus musculus CORO1A MGD MGI:1345961
Macaca mulatta CORO1A VGNC VGNC:71319
Bos taurus CORO1A VGNC VGNC:27620
Canis familiaris CORO1A VGNC VGNC:39527
Rattus norvegicus CORO1A RGD RGD:620009