1. Gene
  2. CHRM5 - cholinergic receptor muscarinic 5 Gene

CHRM5 - cholinergic receptor muscarinic 5 Gene

中文名称:胆碱能受体毒蕈碱 5

种属: Homo sapiens

同用名: HM5

基因 ID: 1133 | 基因类型: protein coding

关于 CHRM5

Cytogenetic location: 15q14 Genomic coordinates (GRCh38): 15:33,968,497-34,067,458 (from NCBI)

This gene has 3 transcripts (splice variants), 264 orthologues and 25 paralogues. Low expression observed in reference dataset.

功能概要

毒蕈碱性胆碱能受体属于更大的 G 蛋白偶联受体家族。这些受体的功能多样性由乙酰胆碱的结合定义,包括腺苷酸环化酶抑制、磷酸肌醇变性和钾通道介导等细胞反应。毒蕈碱受体影响乙酰胆碱在中枢和周围神经系统中的许多作用。该受体的临床意义尚不清楚;然而,已知刺激该受体会增加环 AMP 水平。[RefSeq 提供,2008 年 7 月]

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as Adenylate Cyclase inhibition, phosphoinositide degeneration, and Potassium Channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]

CHRM5 基因产物(2)

mRNA Protein Name
NM_001320917.2 NP_001307846.1 muscarinic acetylcholine receptor M5
NM_012125.4 NP_036257.1 muscarinic acetylcholine receptor M5
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20398705 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CHRM5 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (47 - 495)

  • 0
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  • 500
  • 532 a.a.
蛋白主名 其他名称

muscarinic acetylcholine receptor M5

acetylcholine receptor, muscarinic 5

CHRM5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CHRM5 P08912 CHRM3 Homo sapiens P20309 20398705
种属内
CHRM5 P08912 CHRM3 Homo sapiens P20309 20398705
种属内
CHRM5 P08912 CHRM3 Homo sapiens P20309 20398705
种属内
CHRM5 P08912 CHRM3 Homo sapiens P20309 20398705
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CHRM5 VGNC VGNC:39235
Bos taurus CHRM5 VGNC VGNC:27321
Felis catus CHRM5 VGNC VGNC:60877
Rattus norvegicus CHRM5 RGD RGD:620027
Macaca mulatta CHRM5 VGNC VGNC:71044
Mus musculus CHRM5 MGD MGI:109248