2. Gene
  3. Nox1 - NADPH oxidase 1 Gene

Nox1 - NADPH oxidase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：NADPH 氧化酶1

种属: Rattus norvegicus

基因 ID: 114243 | 基因类型: protein coding

关于 Nox1

Primary_assembly X: 97,279,056-97,302,236 reverse strand.mRatBN7.2:CM026994.1

This gene has 5 transcripts (splice variants), 126 orthologues, 5 paralogues and is associated with 8 phenotypes. Biased expression in Brain (RPKM 13.3), Thymus (RPKM 12.8) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 NAD(P)H 氧化酶 H2O2 形成活性。参与多个过程，包括活性氧代谢过程的正向调节；平滑肌细胞增殖的正调节；和超氧阴离子的产生。 NADPH 氧化酶复合物的一部分。与人 NOX1（NADPH 氧化酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD(P)H oxidase H2O2-forming activity. Involved in several processes, including positive regulation of Reactive Oxygen Species metabolic process; positive regulation of smooth muscle cell proliferation; and superoxide anion generation. Part of NADPH Oxidase complex. Orthologous to human NOX1 (NADPH Oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]

Nox1 基因产物(1)

mRNA Protein Name
NM_053683.2 NP_446135.2 NADPH oxidase 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD(P)H oxidase H2O2-forming activity IMP
IMP: 通过突变表型推断
28317735 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15322091 RGD
enables superoxide-generating NAD(P)H oxidase activity IDA
IDA: 通过直接分析推断
10485709 RGD
enables superoxide-generating NAD(P)H oxidase activity IMP
IMP: 通过突变表型推断
25228390 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell chemotaxis IMP
IMP: 通过突变表型推断
20018867 RGD
involved in cellular response to angiotensin IEP
IEP: 通过表达模式推断
26682942 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
26682942 RGD
involved in cellular response to mercury ion IEP
IEP: 通过表达模式推断
28935286 RGD
involved in cellular response to platelet-derived growth factor stimulus IEP
IEP: 通过表达模式推断
23706097 RGD
involved in glutathione metabolic process IMP
IMP: 通过突变表型推断
30653821 RGD
involved in negative regulation of neuron maturation IMP
IMP: 通过突变表型推断
25617620 RGD
involved in positive regulation of inclusion body assembly IMP
IMP: 通过突变表型推断
23077033 RGD
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
25617620 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
33081375 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: 通过突变表型推断
16254042 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
10485709 RGD
involved in positive regulation of superoxide anion generation IMP
IMP: 通过突变表型推断
24294978 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
23706097 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
23706097 RGD
involved in response to reactive oxygen species IDA
IDA: 通过直接分析推断
11832489 RGD
involved in superoxide anion generation IMP
IMP: 通过突变表型推断
10485709 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NADPH oxidase complex IDA
IDA: 通过直接分析推断
15322091 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nox1 蛋白结构

Ferric_reduct

Ferric_reduct: pfam01794 (73 - 214)

NOX_Duox_like_FAD_NADP

NOX_Duox_like_FAD_NADP: cd06186 (295 - 562)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
蛋白主名 其他名称

NADPH oxidase 1

MOX-1

MOX1

NADH/NADPH mitogenic oxidase subunit p65-mox

NOH-1

NOX-1

mitogenic oxidase 1

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12298 Setanaxib Inhibitor 99.45% Phase 3
HY-120801 APX-115 Inhibitor 99.58% Phase 2
HY-120801A APX-115 free base Inhibitor 98.11% Phase 2
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12805 ML171 Inhibitor 99.82% 否
HY-101499 GKT136901 Inhibitor 99.70% 否
HY-101499A GKT136901 hydrochloride Inhibitor 99.90% 否
HY-P1435 NoxA1ds Inhibitor 95.19% 否
HY-P1435A NoxA1ds TFA Inhibitor / 否
HY-105946 Hidrosmin Inhibitor / 否
HY-128004 ML171 analog 1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nox1 NCBI NCBI:27035
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