2. Gene
  3. Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Uae1

基因 ID: 114711 | 基因类型: protein coding

关于 Gne

功能概要

Enables N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in N-acetylneuraminate biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in GNE myopathy and sialuria. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gne 基因产物(1)

mRNA Protein Name
NM_053765.3 NP_446217.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N-acylmannosamine kinase activity IDA
IDA: 通过直接分析推断
9305887 RGD
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
IDA: 通过直接分析推断
9305887 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
17118363 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cytosol IDA
IDA: 通过直接分析推断
9305887 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UDP-GlcNAc-2-epimerase/ManAc kinase

UDP-N-acetylglucosamine-2-epimerase/N-acetylmannosamine kinase

Gne 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Cross Gne O35826 ZBTB16 Homo sapiens Q05516
Y2H
17118363
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-13246 Apitolisib 99.29% Phase 2
HY-128850 N-Acetyl-D-mannosamine ≥98.0% Phase 2
Pre-clinical Phase
生物活性分子 (76)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100742A (R)-GNE-140 Inhibitor 99.73% 否
HY-147214 GNE-7883 Inhibitor 98.49% 否
HY-108696 GNE-781 Inhibitor 98.16% 否
HY-100343 GNE-495 Inhibitor 99.40% 否
HY-107986 GNE-6776 Inhibitor 98.01% 否
HY-15796 GNE0877 Inhibitor 99.81% 否
HY-108435 GNE-049 Inhibitor 99.40% 否
HY-12947 GNE-3511 Inhibitor 99.07% 否
HY-12632 GNE 2861 Inhibitor 99.20% 否
HY-112937 GNE-6640 Inhibitor 99.91% 否
HY-129939 PROTAC BRD4 ligand-1 Inhibitor 99.85% 否
HY-18163 GNE-7915 Inhibitor 99.82% 否
HY-15766 GNE-617 Inhibitor 99.69% 否
HY-100742 GNE-140 racemate Inhibitor 99.38% 否
HY-135892 GNE-1858 Inhibitor 99.42% 否
HY-129937A GNE-987 Inhibitor 99.91% 否
HY-100726 GNE-272 Inhibitor 99.76% 否
HY-120028 GNE-207 Inhibitor 97.02% 否
HY-149026 GNE-064 Inhibitor 99.75% 否
HY-154984 JET-209 Degrader 98.07% 否
HY-145341 GNE-149 Antagonist 99.66% 否
HY-107409 GNE 5729 Agonist 99.50% 否
HY-12763 GNE-317 Inhibitor 99.14% 否
HY-123621 GNE-375 Inhibitor 99.81% 否
HY-112803 GNE-371 98.21% 否
HY-133736 PROTAC BRD4 Degrader-5-CO-PEG3-N3 99.73% 否
HY-12628 GNE-618 Inhibitor 99.89% 否
HY-10811 GNE-493 Inhibitor 99.81% 否
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% 否
HY-158113 CBPD-409 Degrader / 否
HY-114332 GNE-8505 Inhibitor 99.86% 否
HY-11042 GNE-477 Inhibitor 98.75% 否
HY-19775 GNE-6468 Antagonist 98.04% 否
HY-141551 GNE-274 Degrader 98.93% 否
HY-15883 GNE-900 99.21% 否
HY-12282 GNE-9605 Inhibitor 99.72% 否
HY-129938 PROTAC BRD4 Degrader-24 99.61% 否
HY-142160 GNE-9815 Inhibitor 98.28% 否
HY-19774 GNE-0946 Inhibitor 98.09% 否
HY-123824 GNE-0439 Inhibitor 99.80% 否
HY-12410 GNE-9822 Inhibitor ≥95.0% 否
HY-129527 GNE-9278 Modulator 99.91% 否
HY-149056 GNE-6893 Inhibitor 99.94% 否
HY-150289 GNE-235 98.45% 否
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% 否
HY-100742B (S)-GNE-140 Inhibitor 99.07% 否
HY-108337 GNE-0723 Agonist 98.74% 否
HY-117865 GNE-886 Inhibitor 99.81% 否
HY-112279 GNE-131 Inhibitor 98.15% 否
HY-107498 GNE-8324 Modulator 98.88% 否
HY-149056A (3S,4R)-GNE-6893 Inhibitor 99.49% 否
HY-RS05551 GNE Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-18163A GNE-7915 tosylate Inhibitor 99.69% 否
HY-U00428 GNE 220 Inhibitor / 否
HY-10812 GNE-490 Inhibitor 96.29% 否
HY-126291 GNE-616 Inhibitor / 否
HY-132294 GNE-502 Inhibitor 99.73% 否
HY-128585 GNE684 Inhibitor / 否
HY-134592 Piperidine-GNE-049-N-Boc 98.82% 否
HY-107409B (S,S)-GNE 5729 99.65% 否
HY-107423 GNE 6901 Agonist / 否
HY-124153 GNE-431 Inhibitor / 否
HY-128850S1 N-Acetyl-D-mannosamine-13C / 否
HY-128850S2 N-Acetyl-D-mannosamine-13C-1 / 否
HY-128850S5 N-Acetyl-D-mannosamine-15N / 否
HY-129937 (S)-GNE-987 Inhibitor / 否
HY-132294A (1S,3R)-GNE-502 Inhibitor / 否
HY-13847 GNE-555 Inhibitor / 否
HY-141551B (R)-GNE-274 / 否
HY-148238 GNE-2256 Inhibitor / 否
HY-162553 GNE7599 / 否
HY-16983 GNE-3500 Antagonist / 否
HY-12517 GNE-293 Inhibitor / 否
HY-15882 GNE-783 / 否
HY-101783 GNE-955 Inhibitor / 否
HY-16984 GNE-4997 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gne NCBI NCBI:10020
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