2. Gene
  3. FOXP4 - forkhead box P4 Gene

FOXP4 - forkhead box P4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 P4

种属: Homo sapiens

同用名: hFKHLA

基因 ID: 116113 | 基因类型: protein coding

关于 FOXP4

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,546,381-41,602,384 (from NCBI)

This gene has 9 transcripts (splice variants), 190 orthologues, 4 paralogues and is associated with 1 phenotype. Ubiquitous expression in stomach (RPKM 7.0), testis (RPKM 4.6) and 25 other tissues.

功能概要

该基因属于叉头框 (FOX) 转录因子家族的 P 亚科。 Forkhead box 转录因子在发育和成年期组织和细胞类型特异性基因转录的调节中起着重要作用。叉头盒基因家族的许多成员，包括 P 亚家族的成员，在哺乳动物的肿瘤发生中发挥作用。该基因可能在肾脏和喉部肿瘤的发展中发挥作用。该基因的可变剪接产生多个转录本变体，其中一些编码不同的亚型。[RefSeq 提供，2008 年 7 月]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms. [provided by RefSeq, Jul 2008]

FOXP4 基因产物(6)

mRNA Protein Name
NM_001012426.2 NP_001012426.1 forkhead box protein P4 isoform 1
NM_001012427.2 NP_001012427.1 forkhead box protein P4 isoform 3
NM_001405824.1 NP_001392753.1 forkhead box protein P4 isoform 4
NM_001405825.1 NP_001392754.1 forkhead box protein P4 isoform 5
NM_001405826.1 NP_001392755.1 forkhead box protein P4 isoform 6
NM_138457.3 NP_612466.1 forkhead box protein P4 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19907493 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXP4 蛋白结构

Forkhead

Forkhead: Forkhead domain (467 - 546)

  • 0
  • 200
  • 400
  • 600
  • 680 a.a.
蛋白主名 其他名称

forkhead box protein P4

fork head-related protein like A

FOXP4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXP4 Q8IVH2 FOXP2 Homo sapiens O15409
TAP
25609649
种属内
FOXP4 Q8IVH2 FOXP1 Homo sapiens Q9H334
TAP
25609649
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Ventricular Septal Defect

Ventricular Septal Defects

Interventricular Septal Defect

Heart Septal Defects, Ventricular

Ventricular Septal Abnormality

Interventricular Septum Defect

Ventricular Septum Defect

Vsd - [Ventricular Septum Defect]

Congenital Ventricular Septal Defect

Single Ventricular Septal Defect
Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome

Mental Retardation With Language Impairment And With Or Without Autistic Features

Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects

Intellectual Disability With Language Impairment And With Or Without Autistic Features
Speech Disorder

Speech Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05076 FOXP4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus FOXP4 VGNC VGNC:62346
Macaca mulatta FOXP4 VGNC VGNC:72755
Mus musculus FOXP4 MGD MGI:1921373
Canis familiaris FOXP4 VGNC VGNC:40968
Rattus norvegicus FOXP4 RGD RGD:1311386
Bos taurus FOXP4 VGNC VGNC:29103
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