2. Gene
  3. FOXP1 - forkhead box P1 Gene

FOXP1 - forkhead box P1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 P1

种属: Homo sapiens

同用名: MFH; QRF1; 12CC4; hFKH1B; HSPC215

基因 ID: 27086 | 基因类型: protein coding

关于 FOXP1

Cytogenetic location: 3p13 Genomic coordinates (GRCh38): 3:70,954,708-71,583,978 (from NCBI)

This gene has 71 transcripts (splice variants), 131 orthologues, 42 paralogues and is associated with 104 phenotypes. Ubiquitous expression in lung (RPKM 7.3), ovary (RPKM 7.1) and 25 other tissues.

功能概要

该基因属于叉头框 (FOX) 转录因子家族的 P 亚科。 Forkhead box 转录因子在发育和成年期组织和细胞类型特异性基因转录的调节中起着重要作用。 Forkhead box P1 蛋白包含 DNA 结合域和蛋白质-蛋白质结合域。该基因可能作为肿瘤抑制因子起作用，因为它在几种肿瘤类型中丢失并映射到据报道含有肿瘤抑制基因的染色体区域 (3p14.1) 。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

FOXP1 基因产物(17)

mRNA Protein Name
NM_001012505.2 NP_001012523.1 forkhead box protein P1 isoform b
NM_001244808.3 NP_001231737.1 forkhead box protein P1 isoform c
NM_001244810.2 NP_001231739.1 forkhead box protein P1 isoform d
NM_001244812.3 NP_001231741.1 forkhead box protein P1 isoform e
NM_001244813.3 NP_001231742.1 forkhead box protein P1 isoform f
NM_001244814.3 NP_001231743.1 forkhead box protein P1 isoform a
NM_001244815.2 NP_001231744.2 forkhead box protein P1 isoform f
NM_001244816.2 NP_001231745.1 forkhead box protein P1 isoform a
NM_001349337.2 NP_001336266.2 forkhead box protein P1 isoform i
NM_001349338.3 NP_001336267.1 forkhead box protein P1 isoform a
NM_001349340.3 NP_001336269.1 forkhead box protein P1 isoform a
NM_001349341.3 NP_001336270.1 forkhead box protein P1 isoform j
NM_001349342.3 NP_001336271.1 forkhead box protein P1 isoform f
NM_001349343.3 NP_001336272.1 forkhead box protein P1 isoform i
NM_001349344.3 NP_001336273.1 forkhead box protein P1 isoform i
NM_001370548.1 NP_001357477.1 forkhead box protein P1 isoform k
NM_032682.6 NP_116071.2 forkhead box protein P1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables core promoter sequence-specific DNA binding IDA
IDA: 通过直接分析推断
28218735 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25609649 GOA
enables nuclear androgen receptor binding IDA
IDA: 通过直接分析推断
18640093 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18347093 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IMP
IMP: 通过突变表型推断
30111844 GOA
involved in endothelial cell activation IMP
IMP: 通过突变表型推断
24023716 GOA
involved in macrophage activation IDA
IDA: 通过直接分析推断
18799727 GOA
involved in monocyte activation IDA
IDA: 通过直接分析推断
18799727 GOA
involved in negative regulation of B cell apoptotic process IDA
IDA: 通过直接分析推断
25267198 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
20950788 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
26647308 GOA
involved in negative regulation of androgen receptor signaling pathway IDA
IDA: 通过直接分析推断
18640093 GOA
involved in negative regulation of gene expression IDA
IDA: 通过直接分析推断
30111844 GOA
involved in osteoclast development IDA
IDA: 通过直接分析推断
18799727 GOA
involved in osteoclast differentiation IDA
IDA: 通过直接分析推断
18799727 GOA
involved in positive regulation of B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
30111844 GOA
involved in positive regulation of endothelial cell migration IMP
IMP: 通过突变表型推断
24023716 GOA
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
24023716 GOA
involved in regulation of chemokine (C-X-C motif) ligand 2 production IDA
IDA: 通过直接分析推断
18799727 GOA
involved in regulation of defense response to bacterium IDA
IDA: 通过直接分析推断
18799727 GOA
involved in regulation of endothelial tube morphogenesis IMP
IMP: 通过突变表型推断
24023716 GOA
involved in regulation of gene expression IMP
IMP: 通过突变表型推断
28218735 GOA
involved in regulation of inflammatory response IDA
IDA: 通过直接分析推断
18799727 GOA
involved in regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
18799727 GOA
involved in regulation of interleukin-12 production IDA
IDA: 通过直接分析推断
18799727 GOA
involved in regulation of macrophage colony-stimulating factor production IDA
IDA: 通过直接分析推断
18799727 GOA
involved in regulation of monocyte differentiation IDA
IDA: 通过直接分析推断
15286807 GOA
involved in regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
18799727 GOA
involved in response to lipopolysaccharide IDA
IDA: 通过直接分析推断
18799727 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
25027557 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXP1 蛋白结构

Forkhead

Forkhead: Forkhead domain (465 - 545)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
蛋白主名 其他名称

forkhead box protein P1

fork head-related protein like B

FOXP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXP1 Q9H334 FOXP4 Homo sapiens Q8IVH2
IF
25027557
种属内
FOXP1 Q9H334 FOXP4 Homo sapiens Q8IVH2
TAP
25609649
种属内
FOXP1 Q9H334 FOXP4 Homo sapiens Q8IVH2
Anti Tag CoIP
25027557
种属内
FOXP1 Q9H334 FOXP2 Homo sapiens O15409
TAP
25609649
种属内
FOXP1 Q9H334 FOXP2 Homo sapiens O15409
Anti Tag CoIP
25027557
种属内
FOXP1 Q9H334 FOXP2 Homo sapiens O15409
IF
25027557
种属内
FOXP1 Q9H334 FOXP2 Homo sapiens O15409
IF
25853299
种属内
FOXP1 Q9H334 FOXP1 Homo sapiens Q9H334
Confocal
26647308
种属内
FOXP1 Q9H334 FOXP1 Homo sapiens Q9H334
IF
25853299
种属内
FOXP1 Q9H334 FOXP1 Homo sapiens Q9H334
BRET
25853299
种属内
FOXP1 Q9H334 FOXP1 Homo sapiens Q9H334
TAP
25609649
种属内
FOXP1 Q9H334 FOXP1 Homo sapiens Q9H334
BRET
26647308
种属间: 跨种属相互作用 种属内: 同种属相互作用

FOXP1 抗体

目录号 产品名 应用 反应物种
HY-P81538 FOXP1 Antibody (YA1283) IHC-P Human

关联疾病

疾病名称 别名
Intellectual Disability-Severe Speech Delay-Mild Dysmorphism Syndrome

Foxp1 Syndrome

Mental Retardation With Language Impairment And With Or Without Autistic Features

Foxp1 Related Global Developmental Delay, Intellectual Disability And Speech Defects

Intellectual Disability With Language Impairment And With Or Without Autistic Features
Intellectual Developmental Disorder With Language Impairment And With Or Without Autistic Features

Mental Retardation With Language Impairment And With Or Without Autistic Features

Intellectual Developmental Disorder With Language Impairment With Or Without Autistic Features

MRLIAF
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Atrial Septal Defect 1

ASD1

Atrial Heart Septal Defect 1

Asd
Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma
B-Lymphoblastic Leukemia/Lymphoma With Recurrent Genetic Abnormality
Earlobe Crease
Rare Genetic Intellectual Disability
Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1
Speech Disorder

Speech Disorders
B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos
B-Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B Lymphoblastic Leukemia/Lymphoma, Bcr-Abl1-Like

B-All Bcr-Abl1-Like
Blepharophimosis
Hypogonadotropic Hypogonadism 4 With Or Without Anosmia

HH4

Kallmann Syndrome 4

Kal4

Hypogonadotropic Hypogonadism, Type 4 With/Without Anosmia
Megalencephaly

Macroencephaly

Macrencephaly
Alpha Chain Disease

Seligmann'S Disease

Immunoproliferative Small Intestinal Disease
Orbit Lymphoma

Orbital Lymphoma

Lymphoma Of The Orbit
Speech And Communication Disorders

Language Disorder

Communication Disorder

Language Disorders

Communication Disorders

Speech Language Disorder

Speech-Language Disorder

Communication Impairment

Speech And Language Disorder
Congenital Disorder Of Glycosylation, Type Ig

CDG1G

Alg12-Congenital Disorder Of Glycosylation

Cdg Ig

Congenital Disorder Of Glycosylation Type 1g

Congenital Disorder Of Glycosylation Type Ig

Cdgig

Congenital Disorder Of Glycosylation Ig

Congenital Disorder Of Glycosylation 1g

Cdg-Ig

Alg12-Cdg

Cdg Syndrome Type Ig

Carbohydrate Deficient Glycoprotein Syndrome Type Ig

Mannosyltransferase 8 Deficiency

Glycosylation, Congenital Disorder Of, Type Ig
Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma

Mzl

Mucosa-Associated Lymphoid Tissue Lymphoma
Specific Language Impairment

Language Impairment, Specific
Huntington Disease

Huntington'S Disease

Huntington Chorea

Huntington'S Chorea

HD

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea
Syndromic Intellectual Disability
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05073 FOXP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus FOXP1 VGNC VGNC:29101
Felis catus FOXP1 VGNC VGNC:62345
Mus musculus FOXP1 MGD MGI:1914004
Rattus norvegicus FOXP1 RGD RGD:1308669
Canis familiaris FOXP1 VGNC VGNC:40965
Macaca mulatta FOXP1 VGNC VGNC:84173
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