1. Gene
  2. Bak1 - BCL2-antagonist/killer 1 Gene

Bak1 - BCL2-antagonist/killer 1 Gene

中文名称:BCL2-拮抗因子/杀手 1

种属: Mus musculus

同用名: Bak; N-Bak; N-BAK1

基因 ID: 12018 | 基因类型: protein coding

关于 Bak1

Chromosome 17: 27,238,784-27,247,983 reverse strand.GRCm39:CM001010.3

This gene has 4 transcripts (splice variants), 135 orthologues, 10 paralogues and is associated with 3 phenotypes. Broad expression in large intestine adult (RPKM 19.5), duodenum adult (RPKM 17.1) and 25 other tissues.

功能概要

实现相同的蛋白质结合活性。参与细胞对紫外线的反应和线粒体中细胞色素 c 的释放。作用于多个过程的上游或内部,包括凋亡信号通路;细胞钙离子稳态;和淋巴细胞凋亡过程。位于胞质溶胶中;内质网;和线粒体膜。是线粒体外膜的组成部分。 Bak 复合体的一部分。以多种结构表达,包括消化系统;脑;鳃弓;泌尿生殖系统;和淋巴系统腺体。该基因的人类直系同源物与共济失调毛细血管扩张症和宫颈癌有关。与人类 BAK1(BCL2 拮抗剂/杀手 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables identical protein binding activity. Involved in cellular response to UV and release of cytochrome c from mitochondria. Acts upstream of or within several processes, including apoptotic signaling pathway; cellular calcium ion homeostasis; and lymphocyte apoptotic process. Located in cytosol; endoplasmic reticulum; and mitochondrial membrane. Is integral component of mitochondrial outer membrane. Part of Bak complex. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in ataxia telangiectasia and cervix carcinoma. Orthologous to human BAK1 (BCL2 antagonist/killer 1). [provided by Alliance of Genome Resources, Apr 2022]

Bak1 基因产物(1)

mRNA Protein Name
NM_007523.3 NP_031549.2 bcl-2 homologous antagonist/killer
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
10950869 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10950869 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within B cell apoptotic process IGI
IGI: 通过遗传相互作用推断
16055554 MGI
acts upstream of or within B cell homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within B cell homeostasis IMP
IMP: 通过突变表型推断
16055554 MGI
acts upstream of or within B cell negative selection IGI
IGI: 通过遗传相互作用推断
16055554 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IGI
IGI: 通过遗传相互作用推断
12847083 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
16893972 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IMP
IMP: 通过突变表型推断
11836241 MGI
acts upstream of or within apoptotic process involved in blood vessel morphogenesis IGI
IGI: 通过遗传相互作用推断
15955981 MGI
acts upstream of or within blood vessel remodeling IGI
IGI: 通过遗传相互作用推断
15955981 MGI
acts upstream of calcium ion transport into cytosol IGI
IGI: 通过遗传相互作用推断
15613488 MGI
involved in cellular response to UV IMP
IMP: 通过突变表型推断
15901672 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: 通过直接分析推断
9176392 MGI
acts upstream of establishment of localization in cell IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand IGI
IGI: 通过遗传相互作用推断
15680329 MGI
acts upstream of or within fibroblast apoptotic process IMP
IMP: 通过突变表型推断
15901672 MGI
acts upstream of or within homeostasis of number of cells IGI
IGI: 通过遗传相互作用推断
11163212 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IGI
IGI: 通过遗传相互作用推断
15901672 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage IMP
IMP: 通过突变表型推断
15901672 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IGI
IGI: 通过遗传相互作用推断
12847083 MGI
acts upstream of or within leukocyte homeostasis IGI
IGI: 通过遗传相互作用推断
11163212 MGI
acts upstream of or within limb morphogenesis IGI
IGI: 通过遗传相互作用推断
11163212 MGI
acts upstream of or within mitochondrial fusion IGI
IGI: 通过遗传相互作用推断
16893972 MGI
acts upstream of or within myeloid cell homeostasis IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within negative regulation of endoplasmic reticulum calcium ion concentration IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of peptidyl-serine phosphorylation IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
17068116 MGI
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
26949185 MGI
acts upstream of or within positive regulation of calcium ion transport into cytosol IGI
IGI: 通过遗传相互作用推断
15613488 MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis IGI
IGI: 通过遗传相互作用推断
15955981 MGI
acts upstream of or within regulation of cell cycle IGI
IGI: 通过遗传相互作用推断
16055554 MGI
involved in release of cytochrome c from mitochondria IMP
IMP: 通过突变表型推断
10950869 MGI
acts upstream of or within response to fungus IMP
IMP: 通过突变表型推断
16893972 MGI
acts upstream of or within response to gamma radiation IMP
IMP: 通过突变表型推断
17068116 MGI
acts upstream of or within response to mycotoxin IMP
IMP: 通过突变表型推断
16893972 MGI
acts upstream of or within thymocyte apoptotic process IGI
IGI: 通过遗传相互作用推断
15967824 MGI
acts upstream of or within vagina development IGI
IGI: 通过遗传相互作用推断
11163212 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of BAK complex IDA
IDA: 通过直接分析推断
10950869 MGI
part of BAK complex IPI
IPI: 通过物理相互作用推断
27488021 MGI
located in cytosol IDA
IDA: 通过直接分析推断
12847083 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12847083 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
11146504 MGI
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
11980919 MGI
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
10950869 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
12142566 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Bak1 蛋白结构

Bcl-2_like

Bcl-2_like: cd06845 (26 - 180)

  • 0
  • 100
  • 209 a.a.
蛋白主名 其他名称

bcl-2 homologous antagonist/killer

Bcl2 homologous antagonist/killer

apoptosis regulator BAK

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bak1 NCBI NCBI:578
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