2. Gene
  3. SLC15A4 - solute carrier family 15 member 4 Gene

SLC15A4 - solute carrier family 15 member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 15 成员 4

种属: Homo sapiens

同用名: PHT1; PTR4; FP12591

基因 ID: 121260 | 基因类型: protein coding

关于 SLC15A4

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:128,793,194-128,823,958 (from NCBI)

This gene has 8 transcripts (splice variants), 204 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 17.6), testis (RPKM 10.0) and 25 other tissues.

功能概要

启用 L-组氨酸跨膜转运蛋白活性；肽跨膜转运蛋白活性；和肽聚糖跨膜转运蛋白活性。参与多个过程，包括跨质膜的二肽输入；肽聚糖运输；和 toll 样受体信号通路的正调控。位于内溶酶体膜上。是溶酶体膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables L-histidine transmembrane transporter activity; peptide transmembrane transporter activity; and peptidoglycan transmembrane transporter activity. Involved in several processes, including dipeptide import across plasma membrane; peptidoglycan transport; and positive regulation of Toll-like Receptor signaling pathway. Located in endolysosome membrane. Is integral component of lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC15A4 基因产物(1)

mRNA Protein Name
NM_145648.4 NP_663623.1 solute carrier family 15 member 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-histidine transmembrane transporter activity IDA
IDA: 通过直接分析推断
25238095 GOA
enables dipeptide transmembrane transporter activity IDA
IDA: 通过直接分析推断
29224352 GOA
enables peptide:proton symporter activity IDA
IDA: 通过直接分析推断
25238095 GOA
enables peptidoglycan transmembrane transporter activity IDA
IDA: 通过直接分析推断
25238095 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24695226 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in dipeptide import across plasma membrane IDA
IDA: 通过直接分析推断
29224352 GOA
involved in peptidoglycan transport IDA
IDA: 通过直接分析推断
25238095 GOA
involved in positive regulation of innate immune response IDA
IDA: 通过直接分析推断
32433612 GOA
involved in positive regulation of toll-like receptor 7 signaling pathway IMP
IMP: 通过突变表型推断
25238095 GOA
involved in positive regulation of toll-like receptor 8 signaling pathway IMP
IMP: 通过突变表型推断
32433612 GOA
involved in positive regulation of toll-like receptor 9 signaling pathway IMP
IMP: 通过突变表型推断
25238095 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endolysosome membrane IDA
IDA: 通过直接分析推断
32433612 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
25238095 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC15A4 蛋白结构

PTR2

PTR2: POT family (104 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
蛋白主名 其他名称

solute carrier family 15 member 4

hPHT1

关联疾病

疾病名称 别名
Hypotrichosis 4

HYPT4

Marie Unna Hereditary Hypotrichosis 1

Muhh1

Hypotrichosis, Marie Unna Type, 1

Hypotrichosis Marie Unna 1

Marie Unna Hereditary Hypotrichosis Type 1

Hypotrichosis, Hereditary, Marie Unna Type, 1

Hypotrichosis, Type 4
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149652 IRF5-IN-1 99.91% 否
HY-155863 AJ2-71 99.80% 否
HY-RS13015 SLC15A4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SLC15A4 VGNC VGNC:65203
Macaca mulatta SLC15A4 VGNC VGNC:77557
Rattus norvegicus SLC15A4 RGD RGD:708469
Mus musculus SLC15A4 MGD MGI:2140796
Canis familiaris SLC15A4 VGNC VGNC:52967
Bos taurus SLC15A4 VGNC VGNC:34681
Others SLC15A4 NCBI
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