2. Gene
  3. TASL - TLR adaptor interacting with endolysosomal SLC15A4 Gene

TASL - TLR adaptor interacting with endolysosomal SLC15A4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TLR 适配器与内溶酶体 SLC15A4 相互作用

种属: Homo sapiens

同用名: CXorf21

基因 ID: 80231 | 基因类型: protein coding

关于 TASL

Cytogenetic location: Xp21.2 Genomic coordinates (GRCh38): X:30,558,809-30,577,766 (from NCBI)

This gene has 1 transcript (splice variant) and 185 orthologues. Broad expression in appendix (RPKM 6.3), bone marrow (RPKM 6.2) and 17 other tissues.

功能概要

参与先天免疫反应的正向调节； Toll 样受体信号通路的正向调控；和溶酶体腔 pH 值的调节。位于内溶酶体膜上。 [由基因组资源联盟提供，2022 年 4 月]

Involved in positive regulation of innate immune response; positive regulation of Toll-like Receptor signaling pathway; and regulation of lysosomal lumen pH. Located in endolysosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

TASL 基因产物(1)

mRNA Protein Name
NM_025159.3 NP_079435.1 TLR adapter interacting with SLC15A4 on the lysosome
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of innate immune response IDA
IDA: 通过直接分析推断
32433612 GOA
involved in positive regulation of toll-like receptor 7 signaling pathway IMP
IMP: 通过突变表型推断
32433612 GOA
involved in positive regulation of toll-like receptor 8 signaling pathway IMP
IMP: 通过突变表型推断
32433612 GOA
involved in regulation of lysosomal lumen pH IDA
IDA: 通过直接分析推断
31001245 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endolysosome membrane IDA
IDA: 通过直接分析推断
32433612 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TASL 蛋白结构

DUF4569

DUF4569: Domain of unknown function (DUF4569) (1 - 298)

  • 0
  • 100
  • 200
  • 301 a.a.
蛋白主名 其他名称

TLR adapter interacting with SLC15A4 on the lysosome

5430427O19Rik

TASL 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TASL Q9HAI6 SLC15A4 Homo sapiens Q8N697
TAP
32433612
种属内
TASL Q9HAI6 SLC15A4 Homo sapiens Q8N697
Anti Tag CoIP
33961781
种属内
TASL Q9HAI6 SLC15A4 Homo sapiens Q8N697
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14221 TASL Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TASL VGNC VGNC:52591
Macaca mulatta TASL VGNC VGNC:71573
Rattus norvegicus TASL RGD RGD:1565785
Mus musculus TASL MGD MGI:1918648
Bos taurus TASL VGNC VGNC:56524
Felis catus TASL VGNC VGNC:61301
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