2. Gene
  3. Blm - Bloom syndrome, RecQ like helicase Gene

Blm - Bloom syndrome, RecQ like helicase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

基因 ID: 12144 | 基因类型: protein coding

关于 Blm

功能概要

Enables 3'-5' DNA helicase activity. Involved in G-quadruplex DNA unwinding and replication fork processing. Acts upstream of or within several processes, including DNA metabolic process; negative regulation of thymocyte apoptotic process; and regulation of DNA recombination. Located in chromosome; cytoplasm; and nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and mammary gland. Used to study Bloom syndrome. Human ortholog(s) of this gene implicated in Bloom syndrome. Orthologous to human BLM (BLM RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Blm 基因产物(2)

mRNA Protein Name
NM_001042527.2 NP_001035992.1 recQ-like DNA helicase BLM isoform 2
NM_007550.4 NP_031576.4 recQ-like DNA helicase BLM isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' DNA helicase activity IDA
IDA: 通过直接分析推断
9840919 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15364958 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DN4 thymocyte differentiation IMP
IMP: 通过突变表型推断
17210642 MGI
acts upstream of or within DNA repair IDA
IDA: 通过直接分析推断
15364958 MGI
involved in DNA replication IGI
IGI: 通过遗传相互作用推断
26195664 MGI
involved in DNA replication IMP
IMP: 通过突变表型推断
26195664 MGI
involved in G-quadruplex DNA unwinding IGI
IGI: 通过遗传相互作用推断
26195664 MGI
involved in G-quadruplex DNA unwinding IMP
IMP: 通过突变表型推断
26195664 MGI
acts upstream of or within alpha-beta T cell differentiation IMP
IMP: 通过突变表型推断
17210642 MGI
acts upstream of alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
17210642 MGI
acts upstream of or within cellular response to xenobiotic stimulus IGI
IGI: 通过遗传相互作用推断
25520194 MGI
acts upstream of or within chromosome organization IMP
IMP: 通过突变表型推断
9808625 MGI
acts upstream of immature T cell proliferation in thymus IMP
IMP: 通过突变表型推断
17210642 MGI
acts upstream of mitotic recombination IMP
IMP: 通过突变表型推断
9808625 MGI
involved in negative regulation of mitotic recombination IGI
IGI: 通过遗传相互作用推断
27010503 MGI
acts upstream of or within negative regulation of mitotic recombination IMP
IMP: 通过突变表型推断
9808625 MGI
involved in negative regulation of mitotic recombination IMP
IMP: 通过突变表型推断
27010503 MGI
acts upstream of or within negative regulation of thymocyte apoptotic process IGI
IGI: 通过遗传相互作用推断
11046052 MGI
acts upstream of or within negative regulation of thymocyte apoptotic process IMP
IMP: 通过突变表型推断
11046052 MGI
acts upstream of or within positive regulation of alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
17210642 MGI
acts upstream of or within positive regulation of double-strand break repair via homologous recombination IGI
IGI: 通过遗传相互作用推断
25520194 MGI
acts upstream of or within positive regulation of immature T cell proliferation in thymus IMP
IMP: 通过突变表型推断
17210642 MGI
acts upstream of or within regulation of binding IDA
IDA: 通过直接分析推断
15364958 MGI
involved in replication fork processing IMP
IMP: 通过突变表型推断
29125140 MGI
acts upstream of or within replication-born double-strand break repair via sister chromatid exchange IMP
IMP: 通过突变表型推断
25597246 MGI
acts upstream of or within telomere maintenance IGI
IGI: 通过遗传相互作用推断
15367665 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, telomeric region IMP
IMP: 通过突变表型推断
26195664 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
17982445 MGI
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
17696610 MGI
located in nucleus IDA
IDA: 通过直接分析推断
29125140 MGI
located in pronucleus IDA
IDA: 通过直接分析推断
17982445 MGI
located in replication fork IDA
IDA: 通过直接分析推断
15364958 MGI
located in replication fork IMP
IMP: 通过突变表型推断
26195664 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

recQ-like DNA helicase BLM

Bloom syndrome protein homolog

Bloom syndrome homolog

Bloom syndrome, RecQ helicase-like

bloom syndrome protein homolog

mBLM

recQ helicase homolog

重组 Blm 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72105 BLM Protein, Mouse (His-Myc) O88700 (I684-Q859) ≥95%

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P3239 Belantamab mafodotin 99.60% 否
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12342 ML216 Inhibitor 99.89% 否
HY-110185 NSC 617145 Inhibitor 99.18% 否
HY-111756 BLM-IN-1 Inducer 98.09% 否
HY-128712 NCGC00029283 Inhibitor 98.88% 否
HY-156420 ATUX-1215 Activator 99.94% 否
HY-151939 BLM-IN-2 Inducer / 否
HY-RS01520 BLM Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Blm NCBI NCBI:641
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