2. Apoptosis
  3. Apoptosis
  4. BLM-IN-1

BLM-IN-1 是一种有效的布卢姆综合征蛋白 (BLM) 抑制剂。BLM-IN-1 具有高结合亲和力，KD 值为 1.81 μM。BLM-IN-1 对 BLM 具有良好的抑制作用，IC50 值为 0.95 μM。BLM-IN-1 可诱导细胞凋亡。BLM-IN-1 可用于 DNA 损伤与癌症的研究。

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BLM-IN-1 Chemical Structure

BLM-IN-1 Chemical Structure

CAS No. : 2056014-40-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1530
In-stock
5 mg ￥1500
In-stock
10 mg ￥2500
In-stock
25 mg ￥5500
In-stock
50 mg 现货 询价
100 mg   询价  
200 mg   询价  

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Customer Review

BLM-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BLM-IN-1 is an effective bloom syndrome protein (BLM) inhibitor. BLM-IN-1 has a high binding affinity with a KD valueof 1.81 μM. BLM-IN-1 has good inhibitory effect for BLM with an IC50 value of 0.95 μM. BLM-IN-1 can induce cell apoptosis. BLM-IN-1can be used for the research of DNA damage and cancer[1].

IC50 & Target

IC50: 0.95 μM (BLM)[1].
体外研究
(In Vitro)

BLM-IN-1 (compound 29) has a strong BLM binding with a KD of 1.81 μM[1].
BLM-IN-1 can inhibit BLM with an IC50 of 0.95 μM[1].
BLM-IN-1 (1.0 μM) inhibits the unwinding activity of BLM but also disrupt the BLM binding to DNA[1].
BLM-IN-1 (0-1.0 μM) regulates the homologous recombination by disrupting the recruitment of BLM to DSB sites[1].
BLM-IN-1 (1.0, 2.0 μM; 48 h) induces DNA damage response and apoptosis[1].
BLM-IN-1 (0.1, 1.0, 2.0 μM; 48 h) induces proliferation arrest and synthetic interaction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BLM-IN-1 相关抗体:

Western Blot Analysissup>[1]

Cell Line: HCT116 cells
Concentration: 0.5, 1.0 μM
Incubation Time: 24 h
Result: Obviously upregulated the level of pATM and p-ATR in damage response.

Immunofluorescence[1]

Cell Line: HCT116 cells
Concentration: 1.0 μM
Incubation Time: 24 h
Result: Induced the accumlation of RAD51 at DSB sites.

Cell Proliferation Assay[1]

Cell Line: HCT116 cells
Concentration: 0.1, 1.0, 2.0 μM
Incubation Time: 48 h
Result: Showed a significant proliferation arrest in a dose-dependent manner in HCT116 cells.

Apoptosis Analysis[1]

Cell Line: HCT116 cells
Concentration: 1.0, 2.0 μM
Incubation Time: 48 h
Result: Increased the ratio of apoptosis cells in a concentration-dependent manner and upregulated the expression level of cleaved caspase-3, cleaved caspase-7, and cleaved PARP.
分子量

462.60

Formula

C28H35FN4O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 8.33 mg/mL (18.01 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1617 mL 10.8085 mL 21.6169 mL
5 mM 0.4323 mL 2.1617 mL 4.3234 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

BLM-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1617 mL 10.8085 mL 21.6169 mL 54.0424 mL
5 mM 0.4323 mL 2.1617 mL 4.3234 mL 10.8085 mL
10 mM 0.2162 mL 1.0808 mL 2.1617 mL 5.4042 mL
15 mM 0.1441 mL 0.7206 mL 1.4411 mL 3.6028 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLM-IN-12056014-40-3Apoptosisbloom syndrome protein (BLM)affinityinhibitoryapoptosisDNA damagecancerInhibitorinhibitorinhibit

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目录号：
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