2. Gene
  3. Cd22 - CD22 antigen Gene

Cd22 - CD22 antigen Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lyb8; Lyb-8; A530093D23

基因 ID: 12483 | 基因类型: protein coding

关于 Cd22

功能概要

Enables CD4 receptor binding activity; protein Phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd22 基因产物(2)

mRNA Protein Name
NM_001043317.2 NP_001036782.1 B-cell receptor CD22 precursor
NM_009845.3 NP_033975.3 B-cell receptor CD22 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CD4 receptor binding IPI
IPI: 通过物理相互作用推断
12115612 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9890995 MGI
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
12115612 MGI
enables sialic acid binding IPI
IPI: 通过物理相互作用推断
12115612 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of calcium-mediated signaling IGI
IGI: 通过遗传相互作用推断
20200274 MGI
involved in negative regulation of immunoglobulin production IGI
IGI: 通过遗传相互作用推断
20200274 MGI
involved in regulation of B cell proliferation IGI
IGI: 通过遗传相互作用推断
20200274 MGI
involved in regulation of immune response IGI
IGI: 通过遗传相互作用推断
20200274 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
15095367 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
8418208 MGI
located in neuronal cell body membrane IDA
IDA: 通过直接分析推断
15095367 MGI
located in plasma membrane IPI
IPI: 通过物理相互作用推断
11606382 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

B-cell receptor CD22

B-lymphocyte cell adhesion molecule

BL-CAM

T-cell surface antigen Leu-14

sialic acid-binding Ig-like lectin 2

siglec-2

重组 Cd22 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72474 Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His) AAA02562.1 (S22-R702) ≥95%
HY-P73646 Siglec-2/CD22 Protein, Mouse (690a.a, HEK293, Fc) BAE33829 (R19-R708) ≥95%
HY-P72474A Siglec-2/CD22 Protein, Mouse (HEK293, His) P35329-1 (S22-P702) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (5)
目录号 产品名 作用方式
纯度 Phase
HY-P99264 Inotuzumab Inhibitor ≥95.0% Phase 4
HY-P99289 Epratuzumab 99.46% Phase 3
HY-P99034 Moxetumomab Inhibitor 95.00% Phase 3
HY-P990781 Suciraslimab 97.42% Phase 3
HY-P99230 Pinatuzumab Inhibitor 96.98% Phase 2
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-141602 Pinatuzumab vedotin Inhibitor / 否
HY-146081 CD22 ligand-1 / 否
抗体抑制剂 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990930 Mozistobart / 否
HY-P99464 Bectumomab / 否
HY-P990759 Rezetamig / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cd22 NCBI NCBI:933
Macaca fascicularis Cd22 NCBI NCBI:102130968
Rattus norvegicus Cd22 NCBI NCBI:308501
Macaca mulatta Cd22 NCBI NCBI:106994739
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