Ccr1 - chemokine (C-C motif) receptor 1 Gene

中文名称：趋化因子 (CC 基序) 受体 1

种属: Mus musculus

同用名: Cmkbr1; Mip-1a-R

关于 Ccr1

功能概要

该基因编码的蛋白可启动 CC 趋化因子受体活性。参与先天免疫反应的负调节。作用于炎症反应的上游或内部；白细胞趋化性；和骨髓细胞分化。预测位于神经细胞体和质膜。预计在细胞质和质膜外侧有活性。以多种结构表达，包括背主动脉；胚外成分；肢;肝;和泌尿生殖嵴。用于研究冠状病毒传染病。该基因的人类直系同源物与过敏性接触性皮炎和类风湿性关节炎有关。与人 CCR1（CC 基序趋化因子受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables C-C Chemokine Receptor activity. Involved in negative regulation of innate immune response. Acts upstream of or within inflammatory response; leukocyte chemotaxis; and myeloid cell differentiation. Predicted to be located in neuronal cell body and plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Is expressed in several structures, including dorsal aorta; extraembryonic component; limb; liver; and urogenital ridge. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in allergic contact dermatitis and rheumatoid arthritis. Orthologous to human CCR1 (C-C motif Chemokine Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]