Crebbp - CREB binding protein Gene

中文名称：CREB 结合蛋白

种属: Mus musculus

同用名: CBP; KAT3A; CBP/p300; p300/CBP

关于 Crebbp

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子结合活性； TFIIB 类转录因子结合活性；和无序域特异性结合活性。参与多个过程，包括细胞对病毒的反应；面部形态发生；和干扰素-β产生的负调节。在肝细胞生长因子刺激的细胞反应上游或细胞反应内起作用；种系干细胞群维持；和基因表达的调控。位于染色质和细胞核中。 RNA聚合酶II转录调节复合物的一部分；组蛋白乙酰转移酶复合体；和外着丝粒。以多种结构表达，包括消化系统；胚胎外胚层；泌尿生殖系统；心;和皮肤。用于研究鲁宾斯坦-泰比综合征；急性髓性白血病；自闭症谱系障碍；和骨髓增生异常综合征。该基因的人类直系同源物与 Rubinstein-Taybi 综合征有关；急性淋巴细胞白血病；和急性髓性白血病。与人 CREBBP（CREB 结合蛋白）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription factor binding activity; TFIIB-class transcription factor binding activity; and disordered domain specific binding activity. Involved in several processes, including cellular response to virus; face morphogenesis; and negative regulation of interferon-beta production. Acts upstream of or within cellular response to hepatocyte growth factor stimulus; germ-line stem cell population maintenance; and regulation of gene expression. Located in chromatin and nucleus. Part of RNA polymerase II transcription regulator complex; Histone Acetyltransferase complex; and outer kinetochore. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; heart; and skin. Used to study Rubinstein-Taybi syndrome; acute myeloid leukemia; autism spectrum disorder; and myelodysplastic syndrome. Human ortholog(s) of this gene implicated in Rubinstein-Taybi syndrome; acute lymphoblastic leukemia; and acute myeloid leukemia. Orthologous to human CREBBP (CREB binding protein). [provided by Alliance of Genome Resources, Apr 2022]