2. Gene
  3. Crhr1 - corticotropin releasing hormone receptor 1 Gene

Crhr1 - corticotropin releasing hormone receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：促肾上腺皮质激素释放激素受体 1

种属: Mus musculus

同用名: Crhr; CRF1R; CRFR1

基因 ID: 12921 | 基因类型: protein coding

关于 Crhr1

Biased expression in cerebellum adult (RPKM 7.7), frontal lobe adult (RPKM 4.7) and 6 other tissues.

功能概要

该基因编码的蛋白质是一种 G 蛋白偶联受体，它以高亲和力结合促肾上腺皮质激素释放因子 (CRH) 和尿皮质素 (UCN)。编码的蛋白质上调腺苷酸环化酶活性和细胞内 cAMP 水平。这种蛋白质对于激活调节多种生理过程（包括压力、繁殖、免疫反应和肥胖）的信号转导通路至关重要。已发现该基因编码不同亚型的几种转录变体。 [RefSeq 提供，2015 年 9 月]

The protein encoded by this gene is a G-protein coupled receptor that binds corticotropin-releasing factor (CRH) and urocortin (UCN) with high affinity. The encoded protein upregulates Adenylate Cyclase activity and intracellular cAMP levels. This protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response, and obesity. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Crhr1 基因产物(3)

mRNA Protein Name
NM_007762.5 NP_031788.1 corticotropin-releasing factor receptor 1 isoform 1 precursor
NM_001313929.1 NP_001300858.1 corticotropin-releasing factor receptor 1 isoform 3
NM_001313928.1 NP_001300857.1 corticotropin-releasing factor receptor 1 isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables corticotrophin-releasing factor receptor activity IMP
IMP: 通过突变表型推断
9655498 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
26352593 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9655498 MGI
involved in adrenal gland development IMP
IMP: 通过突变表型推断
9655498 MGI
acts upstream of or within behavioral response to ethanol IMP
IMP: 通过突变表型推断
11988580 MGI
involved in cellular response to corticotropin-releasing hormone stimulus IMP
IMP: 通过突变表型推断
9655498 MGI
involved in corticotropin secretion IMP
IMP: 通过突变表型推断
9655498 MGI
acts upstream of or within exploration behavior IMP
IMP: 通过突变表型推断
29609111 MGI
involved in fear response IMP
IMP: 通过突变表型推断
9655498 MGI
acts upstream of or within general adaptation syndrome, behavioral process IMP
IMP: 通过突变表型推断
11988580 MGI
involved in regulation of corticosterone secretion IMP
IMP: 通过突变表型推断
9655498 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
15183503 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
15183503 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Crhr1 蛋白结构

HormR

HormR: smart00008 (39 - 110)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (115 - 379)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (117 - 142)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (151 - 173)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (188 - 214)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (227 - 247)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (264 - 293)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (307 - 334)

7tmB1_CRF-R1

7tmB1_CRF-R1: cd15445 (341 - 366)

  • 0
  • 100
  • 200
  • 300
  • 415 a.a.
蛋白主名 其他名称

corticotropin-releasing factor receptor 1

CRF 1 receptor

CRF-R-1

CRF-R1

CRF-R1alpha

CRFR-1

CRH-R-1

CRH-R1

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103377 Antalarmin hydrochloride Antagonist 99.87% 否
HY-124475 Antalarmin Antagonist 98.29% 否
HY-12131 DMP 696 Antagonist 99.03% 否
HY-RS03168 CRHR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03169 Crhr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03170 Crhr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Crhr1 NCBI NCBI:1394
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