COPB1 - COPI coat complex subunit beta 1 Gene

中文名称：COPI 外套复杂亚基 beta 1

种属: Homo sapiens

同用名: COPB; BARMACS

基因 ID: 1315 | 基因类型: protein coding

关于 COPB1

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:14,457,512-14,499,811 (from NCBI)

This gene has 12 transcripts (splice variants), 212 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 49.1), prostate (RPKM 35.6) and 25 other tissues.

功能概要

该基因编码与非网格蛋白包被的囊泡相关的外壳复合体的蛋白质亚基。外壳复合体，也称为外壳蛋白复合体 1，在细胞质中形成，并通过活化的鸟苷三磷酸酶募集到高尔基体。一旦到达高尔基体膜，外壳复合体可能有助于将蛋白质和脂质成分移回内质网。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2009 年 1 月]

This gene encodes a protein subunit of the coatomer complex associated with non-clathrin coated vesicles. The coatomer complex, also known as the coat protein complex 1, forms in the cytoplasm and is recruited to the Golgi by activated guanosine triphosphatases. Once at the Golgi membrane, the coatomer complex may assist in the movement of protein and lipid components back to the endoplasmic reticulum. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]

COPB1 基因产物(6)

mRNA	Protein	Name
NM_001144061.2	NP_001137533.1	coatomer subunit beta
NM_001144062.2	NP_001137534.1	coatomer subunit beta
NM_016451.5	NP_057535.1	coatomer subunit beta
NM_001144061.2	NP_001137533.1	coatomer subunit beta
NM_001144062.2	NP_001137534.1	coatomer subunit beta
NM_016451.5	NP_057535.1	coatomer subunit beta

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	10199403	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	7573041	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

COPB1 蛋白结构

Adaptin_N

Coatamer_beta_C

Coatomer_b_Cpla

0
200
400
600
800
953 a.a.

蛋白主名

其他名称

coatomer subunit beta

beta coat protein

COPB1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	COPB1	P53618	SUN2	Homo sapiens	Q9UH99	Pull Down	20551905
Intra	COPB1	P53618	GTPBP4	Homo sapiens	Q9BZE4	Validated Y2H	32296183
Intra	COPB1	P53618	GTPBP4	Homo sapiens	Q9BZE4	Y2H Array	32296183
Intra	COPB1	P53618	GTPBP4	Homo sapiens	Q9BZE4	Y2H Prey Pooling	32296183
Intra	COPB1	P53618	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	COPB1	P53618	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	COPB1	P53618	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	COPB1	P53618	KIAA1328	Homo sapiens	Q86T90	Y2H Prey Pooling	32296183
Intra	COPB1	P53618	KIAA1328	Homo sapiens	Q86T90	Validated Y2H	32296183
Intra	COPB1	P53618	KIAA1328	Homo sapiens	Q86T90	Y2H Array	32296183
Intra	COPB1	P53618	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	COPB1	P53618	BCAR1	Homo sapiens	P56945	Y2H Prey Pooling	32296183
Intra	COPB1	P53618	BCAR1	Homo sapiens	P56945	Validated Y2H	32296183
Intra	COPB1	P53618	BCAR1	Homo sapiens	P56945	Y2H Array	32296183
Intra	COPB1	P53618	TRIM37	Homo sapiens	O94972	Y2H Array	32296183
Intra	COPB1	P53618	TRIM37	Homo sapiens	O94972	Y2H Pooling	16189514
Intra	COPB1	P53618	TRIM37	Homo sapiens	O94972	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Baralle-Macken Syndrome

BARMACS

Neurodevelopmental Disorder With Cataracts And Variable Microcephaly

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Parainfluenza Virus Type 3

Human Parainfluenza Virus Type 3

Piv3

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Suppurative Otitis Media

Otitis Media With Effusion - Purulent	Purulent Otitis Media
Otitis Media, Suppurative

Middle Ear Disease

Middle Ear Anomaly

Disorder Of Middle Ear

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03022	COPB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	COPB1	RGD	RGD:620861
Canis familiaris	COPB1	VGNC	VGNC:39504
Macaca mulatta	COPB1	VGNC	VGNC:71312
Mus musculus	COPB1	MGD	MGI:1917599
Bos taurus	COPB1	VGNC	VGNC:27593
Felis catus	COPB1	VGNC	VGNC:61082

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