ACOT12 - acyl-CoA thioesterase 12 Gene

中文名称：酰基辅酶 A 硫酯酶 12

种属: Homo sapiens

同用名: Cach; THEAL; CACH-1; STARD15

基因 ID: 134526 | 基因类型: protein coding

关于 ACOT12

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:81,308,609-81,394,134 (from NCBI)

This gene has 4 transcripts (splice variants), 143 orthologues and 2 paralogues. Biased expression in liver (RPKM 11.8) and kidney (RPKM 0.6).

功能概要

实现相同的蛋白质结合活性。预计参与酰基辅酶 A 代谢过程和脂肪酸代谢过程。预测作用于乙酰辅酶 A 代谢过程的上游或内部。预计在胞质溶胶中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid metabolic process. Predicted to act upstream of or within acetyl-CoA metabolic process. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ACOT12 基因产物(1)

mRNA	Protein	Name
NM_130767.3	NP_570123.1	acetyl-coenzyme A thioesterase

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACOT12 蛋白结构

4HBT

START

0
100
200
300
400
500
555 a.a.

蛋白主名

其他名称

acetyl-coenzyme A thioesterase

START domain-containing protein 15

ACOT12 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	ACOT12	Q8WYK0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	PAX6	Homo sapiens	P26367	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	ACOT12	Q8WYK0	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	ACOT12	Homo sapiens	Q8WYK0	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	NAA11	Homo sapiens	Q9BSU3	Validated Y2H	32296183
Intra	ACOT12	Q8WYK0	ACOT12	Homo sapiens	Q8WYK0	Validated Y2H	32296183
Intra	ACOT12	Q8WYK0	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	ZBTB8A	Homo sapiens	Q96BR9	Anti Tag CoIP	33961781
Intra	ACOT12	Q8WYK0	ACOT12	Homo sapiens	Q8WYK0	Y2H Array	32296183
Intra	ACOT12	Q8WYK0	PAX6	Homo sapiens	P26367	Y2H Prey Pooling	32296183
Intra	ACOT12	Q8WYK0	ZBTB8A	Homo sapiens	Q96BR9	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Thyroid Dyshormonogenesis 5

TDH5	Hypothyroidism, Congenital, Due To Dyshormonogenesis, 5
Thyroid Hormonogenesis, Genetic Defect In, 5	Genetic Defect In Thyroid Hormonogenesis 5
Chdh5	Congenital Hypothyroidism Due To Dyshormonogenesis Type 5
Genetic Defect In Thyroid Hormonogenesis Type 5

Leukoencephalopathy With Vanishing White Matter

Cree Leukoencephalopathy	Vanishing White Matter Disease
Ovarioleukodystrophy	Vanishing White Matter Leukodystrophy
Childhood Ataxia With Central Nervous System Hypomyelinization	Cach
Cach Syndrome	Myelinosis Centralis Diffusa
VWM	Cle
Childhood Ataxia With Central Nervous System Hypomyelination	Childhood Ataxia With Diffuse Central Nervous System Hypomyelination
Cach/Vwm	Cach/Vwm Syndrome
Childhood Ataxia With Central Nervous System Hypomyelination/Vanishing White Matter	Cree Leukoencehalopathy
Late Infantile Cach Syndrome	Juvenile Or Adult Cach Syndrome
Congenital Or Early Infantile Cach Syndrome	Leukodystrophy With Vanishing White Matter

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00175	ACOT12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	ACOT12	MGD	MGI:1921406
Rattus norvegicus	ACOT12	RGD	RGD:619752
Canis familiaris	ACOT12	VGNC	VGNC:37517
Felis catus	ACOT12	VGNC	VGNC:59519
Macaca mulatta	ACOT12	VGNC	VGNC:69530
Bos taurus	ACOT12	VGNC	VGNC:25548

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