1. Gene
  2. S1pr4 - sphingosine-1-phosphate receptor 4 Gene

S1pr4 - sphingosine-1-phosphate receptor 4 Gene

中文名称:1-磷酸鞘氨醇受体 4

种属: Mus musculus

同用名: Edg6; Lpc1; S1p4

基因 ID: 13611 | 基因类型: protein coding

关于 S1pr4

Chromosome 10: 81,333,581-81,335,966 reverse strand.GRCm39:CM001003.3

This gene has 1 transcript (splice variant), 176 orthologues, 18 paralogues and is associated with 4 phenotypes.

功能概要

该基因编码 G 蛋白偶联受体 1 家族的一个成员。编码的蛋白质是溶血磷脂鞘氨醇 1-磷酸的受体。编码的蛋白质是在 T 细胞中表达的主要鞘氨醇 1-磷酸 G 蛋白偶联受体之一,它在抑制 T 细胞增殖、细胞因子产生和免疫激活的其他潜在方面发挥作用。 [RefSeq 提供,2010 年 2 月]

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The encoded protein is one of the predominant sphingosine 1-phosphate G-protein coupled receptors expressed in T cells, and it plays a role in suppression of T cell proliferation, generation of cytokines, and potentially Other aspects of immune activation. [provided by RefSeq, Feb 2010]

S1pr4 基因产物(1)

mRNA Protein Name
NM_010102.2 NP_034232.1 sphingosine 1-phosphate receptor 4
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11443127 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in presynapse IDA
IDA: 通过直接分析推断
35781853 MGI
is active in presynapse IEP
IEP: 通过表达模式推断
35781853 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

S1pr4 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (50 - 319)

7tm_GPCRs

7tm_GPCRs: cd14964 (51 - 75)

7tm_GPCRs

7tm_GPCRs: cd14964 (84 - 105)

7tm_GPCRs

7tm_GPCRs: cd14964 (121 - 143)

7tm_GPCRs

7tm_GPCRs: cd14964 (165 - 181)

7tm_GPCRs

7tm_GPCRs: cd14964 (202 - 225)

7tm_GPCRs

7tm_GPCRs: cd14964 (251 - 273)

7tm_GPCRs

7tm_GPCRs: cd14964 (287 - 312)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 4

S1P receptor Edg-6

S1p receptor 4

endothelial differentiation G-protein-coupled receptor 6

lysophospholipid receptor C1

sphingosine 1-phosphate receptor Edg-6

直系同源

种属 基因名 来源 基因 ID
Homo sapiens S1pr4 NCBI NCBI:8698