1. Gene
  2. S1PR4 - sphingosine-1-phosphate receptor 4 Gene

S1PR4 - sphingosine-1-phosphate receptor 4 Gene

中文名称:1-磷酸鞘氨醇受体 4

种属: Homo sapiens

同用名: EDG6; LPC1; S1P4; SLP4

基因 ID: 8698 | 基因类型: protein coding

关于 S1PR4

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,178,769-3,180,332 (from NCBI)

This gene has 2 transcripts (splice variants), 176 orthologues and 18 paralogues.

功能概要

该基因是内皮分化、G 蛋白偶联 (EDG) ) 受体基因家族的成员。 EDG 受体结合溶血磷脂或溶血鞘脂作为配体,并参与许多不同细胞类型的细胞信号传导。这种 EDG 受体基因是无内含子的,在淋巴组织中特异性表达。[RefSeq 提供,2008 年 7 月]

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

S1PR4 基因产物(1)

mRNA Protein Name
NM_003775.4 NP_003766.1 sphingosine 1-phosphate receptor 4 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

S1PR4 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (63 - 307)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 4

S1P receptor 4

S1P receptor Edg-6

endothelial differentiation G-protein coupled receptor 6

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 6

sphingosine 1-phosphate receptor Edg-6

关联疾病

疾病名称 别名
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris S1PR4 VGNC VGNC:110551
Rattus norvegicus S1PR4 RGD RGD:1304801
Felis catus S1PR4 VGNC VGNC:64848
Mus musculus S1PR4 MGD MGI:1333809
Bos taurus S1PR4 VGNC VGNC:34255