2. Gene
  3. UPRT - uracil phosphoribosyltransferase homolog Gene

UPRT - uracil phosphoribosyltransferase homolog Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：尿嘧啶磷酸核糖转移酶同系物

种属: Homo sapiens

同用名: UPP; FUR1

基因 ID: 139596 | 基因类型: protein coding

关于 UPRT

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:75,156,369-75,304,897 (from NCBI)

This gene has 9 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in adrenal (RPKM 3.5), thyroid (RPKM 3.4) and 25 other tissues.

功能概要

该基因编码尿嘧啶磷酸核糖转移酶，该酶催化尿嘧啶和 5-磷酸核糖-1-R-二磷酸转化为尿苷一磷酸 (UMP) 。该反应是核苷酸代谢的重要组成部分，特别是嘧啶补救途径。该酶定位于细胞核和细胞质。该蛋白质是合理设计治疗寄生虫感染和癌症药物的潜在目标。[RefSeq 提供，2009 年 11 月]

This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The Enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and Cancer. [provided by RefSeq, Nov 2009]

UPRT 基因产物(3)

mRNA Protein Name
NM_001307944.1 NP_001294873.1 uracil phosphoribosyltransferase homolog isoform 2
NM_001363821.1 NP_001350750.1 uracil phosphoribosyltransferase homolog isoform 3
NM_145052.4 NP_659489.1 uracil phosphoribosyltransferase homolog isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

UPRT 蛋白结构

UPRTase

UPRTase: Uracil phosphoribosyltransferase (116 - 294)

  • 0
  • 100
  • 200
  • 309 a.a.
蛋白主名 其他名称

uracil phosphoribosyltransferase homolog

RP11-311P8.3

UPRT 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Validated Y2H
32296183
种属内
UPRT Q96BW1 GGA3 Homo sapiens Q9NZ52-2
Y2H Array
32296183
种属内
UPRT Q96BW1 COMMD1 Homo sapiens Q8N668
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 COMMD1 Homo sapiens Q8N668
Y2H Array
32296183
种属内
UPRT Q96BW1 POLR2G Homo sapiens P62487
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 POLR2G Homo sapiens P62487
Y2H Array
32296183
种属内
UPRT Q96BW1 KAT5 Homo sapiens Q92993
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 KAT5 Homo sapiens Q92993
Y2H Array
32296183
种属内
UPRT Q96BW1 ERH Homo sapiens P84090
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 ERH Homo sapiens P84090
Y2H Array
32296183
种属内
UPRT Q96BW1 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
UPRT Q96BW1 NPM3 Homo sapiens O75607
Y2H Prey Pooling
32296183
种属内
UPRT Q96BW1 NPM3 Homo sapiens O75607
Y2H Array
32296183
种属内
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Array
32296183
种属内
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Validated Y2H
25416956
种属内
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Array
31515488
种属内
UPRT Q96BW1 PYROXD1 Homo sapiens Q8WU10
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UPRT 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71417 UPRT Protein, Human (His) Q96BW1-1 (M1-D309) ≥95%

关联疾病

疾病名称 别名
Geotrichosis
Breast Fibrosarcoma

Fibrosarcoma Of The Breast
Congenital Toxoplasmosis

Toxoplasmosis, Congenital

Mother-To-Child Transmission Of Toxoplasmosis

Toxoplasma Embryofetopathy

Toxoplasma Embryopathy

Toxoplasmosis - Congen.

Toxoplasmosis Congenital
Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis
Hemophagocytic Lymphohistiocytosis, Familial, 3

Familial Hemophagocytic Lymphohistiocytosis 3

FHL3

Hplh3

Hlh3

Lymphohistiocytosis, Hemophagocytic, Familial, Type 3
Orotic Aciduria

Hereditary Orotic Aciduria

Orotidylic Pyrophosphorylase And Orotidylic Decarboxylase Deficiency

Uridine Monophosphate Synthase Deficiency

Umps Deficiency

Uridine Monophosphate Synthetase Deficiency

Orotic Aciduria I

Orotate Phosphoribosyltransferase And Orotidylic Decarboxylase Deficiency

Oprt And Odc Deficiency

Ump Synthase Deficiency

Orotic Aciduria Ii

Oroticaciduria 1

Orotic Aciduria Hereditary

Orotic Aciduria Type 1

Hereditary Orotic Aciduria Without Megaloblastic Anemia

Orotate Phosphoribosyltransferase And Omp Decarboxylase Deficiency

Ump Synthtase Deficiency

Umps

Orotidylic Decarboxylase Deficiency

Orotic Aciduria 1

ORAC1

Aciduria, Orotic

Hereditary Orotic Aciduria, Type 1

Orotic Aciduria Nos

Orotaciduric Anaemia

Orotic Aciduria Anaemia

Orotic Aciduria Megaloblastic Anaemia
Cryptosporidiosis

Cryptosporidial Gastroenteritis

Intestinal Cryptosporidiosis

Infection By Cryptosporidium

Gastroenteritis Due To Cryptosporidium

Cryptosporidial Infection
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15492 UPRT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris UPRT VGNC VGNC:48158
Rattus norvegicus UPRT RGD RGD:1564806
Bos taurus UPRT VGNC VGNC:36690
Macaca mulatta UPRT VGNC VGNC:81601
Mus musculus UPRT MGD MGI:2685620
Felis catus UPRT VGNC VGNC:97679
Others UPRT NCBI
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