2. Gene
  3. FOXR2 - forkhead box R2 Gene

FOXR2 - forkhead box R2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 R2

种属: Homo sapiens

同用名: FOXN6

基因 ID: 139628 | 基因类型: protein coding

关于 FOXR2

Cytogenetic location: Xp11.21 Genomic coordinates (GRCh38): X:55,623,400-55,626,192 (from NCBI)

This gene has 1 transcript (splice variant), 131 orthologues and 42 paralogues.

功能概要

启用序列特异性双链 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。位于核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FOXR2 基因产物(1)

mRNA Protein Name
NM_198451.4 NP_940853.1 forkhead box protein R2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXR2 蛋白结构

Forkhead

Forkhead: Forkhead domain (192 - 283)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

forkhead box protein R2

forkhead box protein N6

FOXR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra FOXR2 Q6PJQ5 PEF1 Homo sapiens Q9UBV8
Y2H Prey Pooling
25416956
Intra FOXR2 Q6PJQ5 PEF1 Homo sapiens Q9UBV8
Validated Y2H
25416956
Intra FOXR2 Q6PJQ5 PEF1 Homo sapiens Q9UBV8
Validated Y2H
32296183
Intra FOXR2 Q6PJQ5 PEF1 Homo sapiens Q9UBV8
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cns Neuroblastoma With Foxr2 Activation

Central Nervous System Neuroblastoma With Foxr2 Activation

Cns Nb-Foxr2

Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor

Central Nervous System Germ Cell Tumour

Germ Cell Tumor Of The Cns

Germ Cell Tumour Of The Cns
Pineal Gland Cancer

Tumor Of The Pineal Region

Malignant Pineal Region Tumor

Malignant Tumor Of Pineal Gland

Neoplasm Of Pineal Gland

Neoplasm Of The Pineal Region

Pineal Body Neoplasm

Pineocytic Tumor

Malignant Neoplasm Of Pineal Gland

Pineal Gland Neoplasm

Pineocytoma
Pineoblastoma

Pineal Pnet

Pinealoma

Pineal Gland Neoplasm

Pineocytoma

Tumor Of The Pineal Region
Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation

Pineal Parenchymal Tumors Of Intermediate Differentiation

Pptid
Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet

Supratentorial Embryonal Tumor, Not Otherwise Specified

Ewings Sarcoma-Primitive Neuroectodermal Tumor
Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc
Astroblastoma

Cerebral Astroblastoma
Medulloepithelioma

Diktyoma, Malignant

Medulloepithelioma, Central Nervous System

Medulloepithelioma Of The Central Nervous System
Embryonal Tumor With Multilayered Rosettes, C19mc-Altered

Ependymoblastoma
Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet
Atypical Teratoid Rhabdoid Tumor

Rhabdoid Tumor Predisposition Syndrome

Rtps

Atypical Teratoid/Rhabdoid Tumor

Rhabdoid Predisposition Syndrome

Familial Posterior Fossa Brain Tumor Of Infancy

Familial Rhabdoid Tumor

At/Rt

Atypical Teratoid Rhabdoid Tumour

Atypical Teratoid/Rhabdoid Tumour

Rhabdoid Tumor Of The Cns

Rhabdoid Tumour Of The Cns

Familial Posterior Fossa Brain Tumor Syndrome

Hereditary Swi/Snf Deficiency Syndrome

Atrt
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05079 FOXR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FOXR2 VGNC VGNC:40970
Mus musculus FOXR2 MGD MGI:3511682
Bos taurus FOXR2 VGNC VGNC:29105
Rattus norvegicus FOXR2 RGD RGD:1564437
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