CRYGC - crystallin gamma C Gene

中文名称：结晶γC

种属: Homo sapiens

同用名: CCL; CRYG3; CTRCT2

基因 ID: 1420 | 基因类型: protein coding

关于 CRYGC

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:208,128,137-208,129,828 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 95 orthologues, 14 paralogues and is associated with 6 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码 β/γ-晶状体蛋白家族的成员。晶状体蛋白构成脊椎动物眼睛晶状体的主要蛋白质，并维持晶状体的透明度和折射率。该基因和几个家族成员存在于 2 号染色体上的一个基因簇中。该基因的突变已被证明会导致多种类型的白内障，包括 Coppock 样白内障和带状粉末性白内障等。[RefSeq 提供，2015 年 1 月]

This gene encodes a member of the beta/gamma-crystallin family of proteins. Crystallins constitute the major proteins of vertebrate eye lens and maintain the transparency and refractive index of the lens. This gene and several family members are present in a gene cluster on chromosome 2. Mutations in this gene have been shown to cause multiple types of cataract, including Coppock-like cataract and zonular pulverulent cataract, among Others. [provided by RefSeq, Jan 2015]

CRYGC 基因产物(1)

mRNA	Protein	Name
NM_020989.4	NP_066269.1	gamma-crystallin C

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11700327	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in visual perception	IMP IMP: 通过突变表型推断	12011157	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16303126	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16303126	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRYGC 蛋白结构

Crystall

0
100
174 a.a.

蛋白主名

其他名称

gamma-crystallin C

gamma-crystallin 2-1

CRYGC 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CRYGC	P07315	CRYGB	Homo sapiens	P07316	Anti Tag CoIP	33961781
种属内	CRYGC	P07315	CRYGB	Homo sapiens	P07316	Anti Tag CoIP	28514442
种属内	CRYGC	P07315	TRIM7	Homo sapiens	Q9C029	Y2H Prey Pooling	32296183
种属内	CRYGC	P07315	TRIM7	Homo sapiens	Q9C029	Validated Y2H	32296183
种属内	CRYGC	P07315	TRIM7	Homo sapiens	Q9C029	Y2H Array	32296183
种属内	CRYGC	P07315	CRYAA	Homo sapiens	P02489	CoIP	11700327
种属内	CRYGC	P07315	CRYAB	Homo sapiens	P02511	CoIP	11700327

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cataract 2, Multiple Types

CTRCT2	Cataract, Coppock-Like
Cataract 2, Multiple Types, With Or Without Microcornea	Ccl
Cataract 2 Multiple Types	Cataract 2 Multiple Types With Or Without Microcornea
Cataract Coppock-Like	Cataract Embryonic Nuclear
Variable Zonular Pulverulent Cataract	Cataract, Variable Zonular Pulverulent

Cataract 30, Multiple Types

CTRCT30	Cataract 30, Pulverulent
Pulverulent Cataract	Coppock-Like Cataract
Dusty Cataract	Pulverulent Cataract 30
Cataract 30	Cataract, Pulverulent

Cataract Microcornea Syndrome

Microcornea Cataract Syndrome

Cataract-Microcornea Syndrome

Early-Onset Lamellar Cataract

Early-Onset Nuclear Cataract

Cataract

Cataracts	Cat - [Cataract]
Cataract Form	Lens Opacity
Lens Opacities

Zebrafish Allergy

Danio Rerio Allergy

Pontocerebellar Hypoplasia, Type 14

PCH14	Pontocerebellar Hypoplasia Type 14
Pontocerebellar Hypoplasia 14	Doid:0112325

Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc

Monkeypox

Monkeypox Virus Infections

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Arthrogryposis, Distal, Type 2b3

DA2B3	Distal Arthrogryposis Type 2b3
Arthrogryposis, Distal, 2b3

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Polyposis Syndrome, Hereditary Mixed, 2

HMPS2	Hereditary Mixed Polyposis Syndrome 2
Polyposis Syndrome, Mixed Hereditary 2	Polyposis Syndrome, Hereditary Mixed, Type 2

Gastric Hemangioma

Hemangioma Of Stomach

Breast Adenocarcinoma

Mammary Adenocarcinoma

Adenocarcinoma Of Breast

Osebold-Remondini Syndrome

Brachydactyly Type A6	Brachymesophalangy With Mesomelic Short Limbs And Carpal And Tarsal Osseous Abnormalities
Bda6	Brachydactyly, Type A6

Bladder Clear Cell Adenocarcinoma

Bladder Mesonephric Adenocarcinoma

Clear Cell Adenocarcinoma Of Bladder

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03214	CRYGC Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CRYGC	VGNC	VGNC:27741
Canis familiaris	CRYGC	VGNC	VGNC:57380
Mus musculus	CRYGC	MGD	MGI:88523
Rattus norvegicus	CRYGC	RGD	RGD:2421

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4