2. Gene
  3. CSTA - cystatin A Gene

CSTA - cystatin A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胱抑素 A

种属: Homo sapiens

同用名: AREI; PSS4; STF1; STFA

基因 ID: 1475 | 基因类型: protein coding

关于 CSTA

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,325,248-122,341,969 (from NCBI)

This gene has 2 transcripts (splice variants), 208 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in esophagus (RPKM 1149.9), skin (RPKM 100.5) and 1 other tissue.

功能概要

胱抑素超家族包括含有多个胱抑素样序列的蛋白质。一些成员是活性半胱氨酸蛋白酶抑制剂，而其他成员则失去或可能从未获得这种抑制活性。超家族中有三个抑制家族，包括 1 型胱抑素 (stefins) 、2 型胱抑素和激肽原。该基因编码的 stefin 作为半胱氨酸蛋白酶抑制剂，与木瓜蛋白酶和组织蛋白酶 B、H 和 L 形成紧密复合物。该蛋白是角质形成细胞角化细胞包膜的前体蛋白之一，在表皮发育和维护。 Stefins 已被提议作为癌症的预后和诊断工具。[RefSeq 提供，2008 年 7 月]

The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine Protease Inhibitors, while Others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for Cancer. [provided by RefSeq, Jul 2008]

CSTA 基因产物(1)

mRNA Protein Name
NM_005213.4 NP_005204.1 cystatin-A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase inhibitor activity IDA
IDA: 通过直接分析推断
3488317 GOA
enables protease binding IPI
IPI: 通过物理相互作用推断
6203523 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11152132 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion IMP
IMP: 通过突变表型推断
21944047 GOA
involved in keratinocyte differentiation IDA
IDA: 通过直接分析推断
10908733 GOA
involved in negative regulation of peptidase activity IDA
IDA: 通过直接分析推断
6203523 GOA
involved in negative regulation of proteolysis IDA
IDA: 通过直接分析推断
3488317 GOA
involved in peptide cross-linking IDA
IDA: 通过直接分析推断
10908733 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cornified envelope IDA
IDA: 通过直接分析推断
10908733 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
21944047 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
3488317 GOA
part of peptidase inhibitor complex IPI
IPI: 通过物理相互作用推断
20860624 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CSTA 蛋白结构

Cystatin

Cystatin: Cystatin domain (4 - 91)

  • 0
  • 98 a.a.
蛋白主名 其他名称

cystatin-A

cystatin A (stefin A)

CSTA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CSTA P01040 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
种属内
CSTA P01040 HSPB1 Homo sapiens P04792
Y2H Array
32814053
种属内
CSTA P01040 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
种属内
CSTA P01040 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
CSTA P01040 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
CSTA P01040 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
CSTA P01040 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
CSTA P01040 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
CSTA P01040 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
CSTA P01040 CTSB Homo sapiens P07858
Anti Tag CoIP
33961781
种属内
CSTA P01040 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
CSTA P01040 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
CSTA P01040 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属间
CSTA P01040 papa1_carpa Carica papaya P00784
Fluorescence
11152132
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CSTA 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7868 Cystatin A/CSTA Protein, Human (His) P01040 (I2-F98) ≥95%

CSTA 抗体

目录号 产品名 应用 反应物种
HY-P83015 Cystatin A Antibody (YA2760) WB, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Peeling Skin Syndrome 4

PSS4

Arei

Exfoliative Ichthyosis, Autosomal Recessive

Ichthyosis Bullosa Of Siemens-Like

Ichthyosis, Exfoliative, Autosomal Recessive

Exfoliative Ichthyosis Autosomal Recessive Ibs-Like

Ichthyosis, Exfoliative, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like

Skin, Peeling, Syndrome, Type 4

Exfoliative Ichthyosis, Autosomal Recessive, Ichthyosis Bullosa Of Siemens-Like
Peeling Skin Syndrome 2

Acral Peeling Skin Syndrome

Peeling Skin Syndrome, Acral Type

Apss

PSS2

Acral Pss

Acral Deciduous Skin

Localized Pss

Localized Deciduous Skin

Peeling Skin Syndrome Type A

Skin, Peeling, Syndrome, Type 2
Exfoliative Ichthyosis

Ichthyosis Exfoliativa

Autosomal Recessive Exfoliative Ichthyosis
Peeling Skin Syndrome

Deciduous Skin

Familial Continuous Skin Peeling Syndrome

Idiopathic Deciduous Skin

Keratosis Exfoliativa Congenita

Pss

Peeling Skin Disease

Skin Peeling Syndrome

Familial Continuous Skin Peeling

Keratolysis Exfoliativa Congenita

Exfoliation Syndrome

Keratolysis Exfoliativa
Ichthyosis Bullosa Of Siemens

IBS

Ichthyosis, Bullous Type

Bullous Type Of Ichthyosis

Ichthyosis Bullous Type
Ichthyosis

Ichthyoses

Non-Syndromic Ichthyosis

Congenital Ichthyosis
Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary
Psoriasis
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03271 CSTA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus CSTA VGNC VGNC:97176
Rattus norvegicus CSTA RGD RGD:1309603
Canis familiaris CSTA VGNC VGNC:39681
Bos taurus CSTA VGNC VGNC:27779
Macaca mulatta CSTA VGNC VGNC:71533
Others CSTA NCBI
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