2. Gene
  3. Haspin - histone H3 associated protein kinase Gene

Haspin - histone H3 associated protein kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：组蛋白 H3 相关蛋白激酶

种属: Mus musculus

同用名: Gsg2

基因 ID: 14841 | 基因类型: protein coding

关于 Haspin

Chromosome 11: 73,026,311-73,029,120 reverse strand.GRCm39:CM001004.3

This gene has 1 transcript (splice variant), 174 orthologues, 4 paralogues and is associated with 1 phenotype.

功能概要

该基因编码的蛋白可启动 ATP 绑定活动； DNA结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与细胞内信号转导和蛋白质磷酸化。在有丝分裂细胞周期的 G1/S 转换负调节的上游或负调节中起作用。位于核内。与人类 HASPIN（组蛋白 H3 相关蛋白激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity; DNA binding activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction and protein phosphorylation. Acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle. Located in nucleus. Orthologous to human HASPIN (histone H3 associated protein kinase). [provided by Alliance of Genome Resources, Apr 2022]

Haspin 基因产物(1)

mRNA Protein Name
NM_010353.2 NP_034483.1 serine/threonine-protein kinase haspin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
10358056 MGI
enables DNA binding IDA
IDA: 通过直接分析推断
10358056 MGI
enables histone kinase activity IMP
IMP: 通过突变表型推断
25645018 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10358056 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome organization involved in meiotic cell cycle IMP
IMP: 通过突变表型推断
25645018 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
25645018 MGI
involved in homologous chromosome segregation IMP
IMP: 通过突变表型推断
25645018 MGI
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
10358056 MGI
involved in meiotic cell cycle process IMP
IMP: 通过突变表型推断
25645018 MGI
involved in meiotic metaphase I IMP
IMP: 通过突变表型推断
25645018 MGI
acts upstream of or within negative regulation of G1/S transition of mitotic cell cycle IDA
IDA: 通过直接分析推断
10358056 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
10358056 MGI
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
25645018 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
10358056 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10358056 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Haspin 蛋白结构

PKc_like

PKc_like: cl21453 (390 - 746)

  • 0
  • 200
  • 400
  • 600
  • 754 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase haspin

germ cell associated 2, haspin

germ cell-specific gene 2 protein

haploid germ cell-specific nuclear protein kinase

相关产品

Pre-clinical Phase
生物活性分子 (17)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15424 5-Iodotubercidin Inhibitor 99.64% 否
HY-15217 CHR-6494 Inhibitor 98.07% 否
HY-13455 LDN-192960 Inhibitor 99.56% 否
HY-146636 Haspin-IN-3 Inhibitor 98.14% 否
HY-110320 LDN-209929 dihydrochloride Inhibitor 98.43% 否
HY-13455A LDN-192960 hydrochloride Inhibitor 99.78% 否
HY-100368 MELK-8a Inhibitor 98.32% 否
HY-110350 CHR-6494 TFA Inhibitor / 否
HY-146586 Haspin-IN-1 Inhibitor / 否
HY-146587 Haspin-IN-2 Inhibitor / 否
HY-155341 HSK205 Inhibitor / 否
HY-163858 Haspin-IN-4 Inhibitor / 否
HY-170546 MU1920 Inhibitor / 否
HY-RS06009 HASPIN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06010 Haspin Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06011 Haspin Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-135002 LDN-209929 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Haspin NCBI NCBI:83903
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