2. Gene
  3. PPP1R1C - protein phosphatase 1 regulatory inhibitor subunit 1C Gene

PPP1R1C - protein phosphatase 1 regulatory inhibitor subunit 1C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 1 调节抑制因子亚基 1C

种属: Homo sapiens

同用名: IPP5

基因 ID: 151242 | 基因类型: protein coding

关于 PPP1R1C

Cytogenetic location: 2q31.3-q32.1 Genomic coordinates (GRCh38): 2:181,954,480-182,131,385 (from NCBI)

This gene has 13 transcripts (splice variants), 187 orthologues and 2 paralogues. Biased expression in heart (RPKM 4.6), testis (RPKM 4.4) and 5 other tissues.

功能概要

蛋白磷酸酶 1 (PP1) 是一种主要的丝氨酸/苏氨酸磷酸酶，可调节多种细胞功能。 PP1 由一个催化亚基 (参见 PPP1CA；MIM 176875) 和决定 PP1 亚细胞定位或调节其功能的调节亚基组成。 PPP1R1C 属于一组 PP1 抑制亚基，它们本身受磷酸化调节 (Wang 等人，2008 [PubMed 18310074]) 。[OMIM 提供，2010 年 2 月]

Protein phosphatase-1 (PP1) is a major serine/threonine Phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

PPP1R1C 基因产物(3)

mRNA Protein Name
NM_001080545.3 NP_001074014.1 protein phosphatase 1 regulatory subunit 1C isoform 2
NM_001261424.2 NP_001248353.1 protein phosphatase 1 regulatory subunit 1C isoform 1
NM_001261425.2 NP_001248354.1 protein phosphatase 1 regulatory subunit 1C isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPP1R1C 蛋白结构

DARPP-32

DARPP-32: Protein phosphatase inhibitor 1/DARPP-32 (1 - 105)

  • 0
  • 100
  • 109 a.a.
蛋白主名 其他名称

protein phosphatase 1 regulatory subunit 1C

PP1 inhibitor protein 5

关联疾病

疾病名称 别名
Conduct Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10994 PPP1R1C Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus PPP1R1C VGNC VGNC:33235
Canis familiaris PPP1R1C VGNC VGNC:44888
Felis catus PPP1R1C VGNC VGNC:80317
Macaca mulatta PPP1R1C VGNC VGNC:76256
Mus musculus PPP1R1C MGD MGI:1923185
Rattus norvegicus PPP1R1C RGD RGD:1562095
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