2. Gene
  3. DAP - death associated protein Gene

DAP - death associated protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：死亡相关蛋白

种属: Homo sapiens

同用名: DAP1

基因 ID: 1611 | 基因类型: protein coding

关于 DAP

Cytogenetic location: 5p15.2 Genomic coordinates (GRCh38): 5:10,679,230-10,761,234 (from NCBI)

This gene has 6 transcripts (splice variants), 167 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 62.5), urinary bladder (RPKM 56.2) and 25 other tissues.

功能概要

该基因编码一种基本的、富含脯氨酸的 15-kD 蛋白质。该蛋白质充当由干扰素-γ 诱导的程序性细胞死亡的正介质。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 5 月]

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

DAP 基因产物(2)

mRNA Protein Name
NM_001291963.2 NP_001278892.1 death-associated protein 1 isoform 1
NM_004394.3 NP_004385.1 death-associated protein 1 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables death domain binding IPI
IPI: 通过物理相互作用推断
1087798 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
1087798 GOA
acts upstream of or within apoptotic process IGI
IGI: 通过遗传相互作用推断
7828849 GOA
involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
1087798 GOA
involved in cellular response to amino acid starvation IDA
IDA: 通过直接分析推断
20537536 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
1087798 GOA
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
1087798 GOA
involved in negative regulation of autophagy IMP
IMP: 通过突变表型推断
20537536 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DAP 蛋白结构

DAP

DAP: Death-associated protein (12 - 102)

  • 0
  • 102 a.a.
蛋白主名 其他名称

death-associated protein 1

DAP-1

DAP 抗体

目录号 产品名 应用 反应物种
HY-P82896 DAP1 Antibody (YA2641) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Alpha-Thalassemia

Alpha Thalassemia

Alpha Thalassaemia

Alpha Plus Thalassemia

Thalassemia, Alpha-

Thalassemias, Alpha-

A-Thalassemia

Α-Thalassemia

A-THAL

Thalassemia

Alpha Thalassaemia Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (61)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100714A D-AP5 Antagonist 99.94% 否
HY-P1070 Amylin, amide, human 98.02% 否
HY-P4931 Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 99.87% 否
HY-33046 N-Boc-dolaproine Inhibitor 99.96% 否
HY-78931 Boc-Dap-NE 99.94% 否
HY-78932A Dap-NE hydrochloride 99.99% 否
HY-W010962 Fmoc-Dap(Alloc)-OH 99.59% 否
HY-W010922 Fmoc-Dap(Boc)-OH 99.98% 否
HY-P1070A Amylin, amide, human TFA 98.76% 否
HY-W047799 Boc-Dap(Boc)-OH ≥95.0% 否
HY-W046355 Fmoc-D-Dap(Boc)-OH 99.56% 否
HY-W008325 Boc-L-Dap-OH ≥98.0% 否
HY-W048673 Fmoc-Phe(4-CONH2)-OH 99.35% 否
HY-144022 16:0 DAP ≥98.0% 否
HY-164170 Photocaged DAP 98.13% 否
HY-130961 Boc-Val-Dil-Dap-OH 98.52% 否
HY-78931A (R,S,S,R,S)-Boc-Dap-NE / 否
HY-P3120 Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2 96.30% 否
HY-W014692 Boc-D-2,3-diaminopropionic acid ≥97.0% 否
HY-151715 N3-D-Dap(Fmoc)-OH 99.87% 否
HY-78931B (S,S,S,S,R)-Boc-Dap-NE / 否
HY-78931C (S,S,R,S,R)-Boc-Dap-NE / 否
HY-78931E (R,S,R,S,R)-Boc-Dap-NE / 否
HY-78931F (R,S,S,S,R)-Boc-Dap-NE / 否
HY-78931G Boc-Dap-NE (GMP) / 否
HY-78932G Dap-NE (hydrochloride) (GMP) / 否
HY-100714B L-AP5 Antagonist / 否
HY-100781 D-AP4 Antagonist / 否
HY-118316 GSK223 Inhibitor / 否
HY-121634 DAP-81 Inhibitor / 否
HY-130956 Boc-NMe-Val-Val-Dil-Dap-OH / 否
HY-130975 Boc-Val-Dil-Dap-Phe-OMe / 否
HY-130976 N-Boc-Val-Dil-Dap-Doe / 否
HY-143700 18:0 DAP / 否
HY-144020 14:0 DAP / 否
HY-151640 Fmoc-DAP-N3 / 否
HY-154981 Mal-L-Dap(Boc)-OSu / 否
HY-160795 Boc-NMeVal-Val-Dil-Dap / 否
HY-164787 N-MeVal-Val-Dil-Dap-2-(pyridin-3-yl)ethanamine Inhibitor / 否
HY-P1274 ShK-Dap22 Inhibitor / 否
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / 否
HY-P3477 Mca-PLA-Nva-Dap(Dnp)-AR-NH2 / 否
HY-P4905 Mca-Pro-Leu-Gly-Leu-Glu-Glu-Ala-Dap(Dnp)-NH2 Inhibitor / 否
HY-P5524 C12-iE-DAP Agonist / 否
HY-RS03525 DAP Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03526 DAP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W109214 Fmoc-L-Dap(Boc,Me)-OH / 否
HY-W337644 Fmoc-L-Homoarg(Et)2-OH hydrochloride / 否
HY-107719 D-AP7 / 否
HY-151736 N3-L-Dap(Boc)-OH / 否
HY-151780 Fmoc-L-Dap(Pentynoyl)-OH / 否
HY-151781 Fmoc-L-Dap(Poc)-OH / 否
HY-151849 Z-L-Dap(N3)-OH / 否
HY-162819 Apoptosis inducer 26 Inducer / 否
HY-164867 Fmoc-L-Dap(NBSD)-OH / 否
HY-78932 Dap-NE / 否
HY-78932C (2S,3R)-Dap-NE hydrochloride Inhibitor / 否
HY-78932D (2R,3R)-Dap-NE hydrochloride / 否
HY-P4931A Mca-KPLGL-Dap(Dnp)-AR-NH2 TFA / 否
HY-P5523 iE-DAP Agonist / 否
HY-W250408 Fmoc-NMe-Val-Val-Dil-Dap-OH / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus DAP RGD RGD:620641
Bos taurus DAP VGNC VGNC:50122
Macaca mulatta DAP VGNC VGNC:71730
Mus musculus DAP MGD MGI:1918190
Others DAP NCBI
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