Il13 - interleukin 13 Gene

中文名称：白细胞介素 13

种属: Mus musculus

同用名: Il-13

关于 Il13

功能概要

预计该基因编码的蛋白可启动白细胞介素 13 受体结合活性。参与冷诱导产热的正向调节和巨噬细胞活化的正向调节。在对细胞因子刺激的细胞反应的上游或内部起作用；炎症反应；和免疫效应过程的正调节。位于细胞质中；质膜的外侧；和细胞外空间。在肠道中表达；肝;雄性生殖腺或器官；和胸腺。用于研究特应性皮炎。该基因的人类直系同源物与多种疾病有关，包括过敏性疾病（多种）；自身免疫性疾病（多种）；弥漫性硬皮病;肺部疾病（多发）；和鼻子疾病（多种）。与人 IL13（白细胞介素 13）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable interleukin-13 receptor binding activity. Involved in positive regulation of cold-induced thermogenesis and positive regulation of macrophage activation. Acts upstream of or within cellular response to cytokine stimulus; inflammatory response; and positive regulation of immune effector process. Located in cytoplasm; external side of plasma membrane; and extracellular space. Is expressed in gut; liver; male reproductive gland or organ; and thymus. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); autoimmune disease (multiple); diffuse scleroderma; lung disease (multiple); and nose disease (multiple). Orthologous to human IL13 (interleukin 13). [provided by Alliance of Genome Resources, Apr 2022]